Electrocatalytic on-site oxygenation for transplanted cell-based-therapies

Inkyu Lee, Abhijith Surendran, Samantha Fleury, Ian Gimino, Alexander Curtiss, Cody Fell, Daniel J. Shiwarski, Omar Refy, Blaine Rothrock, Seonghan Jo, Tim Schwartzkopff, Abijeet Singh Mehta, Yingqiao Wang, Adam Sipe, Sharon John, Xudong Ji, Georgios Nikiforidis, Adam W. Feinberg, Josiah Hester, Douglas J. Weber, Omid Veiseh, Jonathan Rivnay () and Tzahi Cohen-Karni ()
Additional contact information
Inkyu Lee: Carnegie Mellon University
Abhijith Surendran: Northwestern University
Samantha Fleury: Rice University
Ian Gimino: Carnegie Mellon University
Alexander Curtiss: Northwestern University
Cody Fell: Rice University
Daniel J. Shiwarski: Carnegie Mellon University
Omar Refy: Carnegie Mellon University
Blaine Rothrock: Northwestern University
Seonghan Jo: Carnegie Mellon University
Tim Schwartzkopff: Carnegie Mellon University
Abijeet Singh Mehta: Northwestern University
Yingqiao Wang: Carnegie Mellon University
Adam Sipe: The Pennsylvania State University
Sharon John: Carnegie Mellon University
Xudong Ji: Northwestern University
Georgios Nikiforidis: Northwestern University
Adam W. Feinberg: Carnegie Mellon University
Josiah Hester: Georgia Institute of Technology
Douglas J. Weber: Carnegie Mellon University
Omid Veiseh: Rice University
Jonathan Rivnay: Northwestern University
Tzahi Cohen-Karni: Carnegie Mellon University

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract Implantable cell therapies and tissue transplants require sufficient oxygen supply to function and are limited by a delay or lack of vascularization from the transplant host. Previous exogenous oxygenation strategies have been bulky and had limited oxygen production or regulation. Here, we show an electrocatalytic approach that enables bioelectronic control of oxygen generation in complex cellular environments to sustain engineered cell viability and therapy under hypoxic stress and at high cell densities. We find that nanostructured sputtered iridium oxide serves as an ideal catalyst for oxygen evolution reaction at neutral pH. We demonstrate that this approach exhibits a lower oxygenation onset and selective oxygen production without evolution of toxic byproducts. We show that this electrocatalytic on site oxygenator can sustain high cell loadings (>60k cells/mm3) in hypoxic conditions in vitro and in vivo. Our results showcase that exogenous oxygen production devices can be readily integrated into bioelectronic platforms, enabling high cell loadings in smaller devices with broad applicability.

Date: 2023
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DOI: 10.1038/s41467-023-42697-2

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