Indocyanine green fluorescence imaging-guided versus conventional laparoscopic lymphadenectomy for gastric cancer: long-term outcomes of a phase 3 randomised clinical trial

Qi-Yue Chen, Qing Zhong, Zhi-Yu Liu, Ping Li, Guang-Tan Lin, Qiao-Ling Zheng, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Gui-Rong Zeng, Mei-Chen Jiang, Hua-Gen Wang, Xiao-Bo Huang, Kai-Xiang Xu, Yi-Fan Li, Chao-Hui Zheng (), Jian-Wei Xie () and Chang-Ming Huang ()
Additional contact information
Qi-Yue Chen: Fujian Medical University Union Hospital
Qing Zhong: Fujian Medical University Union Hospital
Zhi-Yu Liu: Fujian Medical University Union Hospital
Ping Li: Fujian Medical University Union Hospital
Guang-Tan Lin: Fujian Medical University Union Hospital
Qiao-Ling Zheng: Fujian Medical University Union Hospital
Jia-Bin Wang: Fujian Medical University Union Hospital
Jian-Xian Lin: Fujian Medical University Union Hospital
Jun Lu: Fujian Medical University Union Hospital
Long-Long Cao: Fujian Medical University Union Hospital
Mi Lin: Fujian Medical University Union Hospital
Ru-Hong Tu: Fujian Medical University Union Hospital
Ze-Ning Huang: Fujian Medical University Union Hospital
Gui-Rong Zeng: Fujian Medical University
Mei-Chen Jiang: Fujian Medical University Union Hospital
Hua-Gen Wang: Fujian Medical University Union Hospital
Xiao-Bo Huang: Fujian Medical University Union Hospital
Kai-Xiang Xu: Fujian Medical University Union Hospital
Yi-Fan Li: Fujian Medical University Union Hospital
Chao-Hui Zheng: Fujian Medical University Union Hospital
Jian-Wei Xie: Fujian Medical University Union Hospital
Chang-Ming Huang: Fujian Medical University Union Hospital

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract Indocyanine green (ICG) fluorescence imaging-guided lymphadenectomy has been demonstrated to be effective in increasing the number of lymph nodes (LNs) retrieved in laparoscopic gastrectomy for gastric cancer (GC). Previously, we reported the primary outcomes and short-term secondary outcomes of a phase 3, open-label, randomized clinical trial (NCT03050879) investigating the use of ICG for image-guided lymphadenectomy in patients with potentially resectable GC. Patients were randomly (1:1 ratio) assigned to either the ICG or non-ICG group. The primary outcome was the number of LNs retrieved and has been reported. Here, we report the primary outcome and long-term secondary outcomes including three-year overall survival (OS), three-year disease-free survival (DFS), and recurrence patterns. The per-protocol analysis set population is used for all analyses (258 patients, ICG [n = 129] vs. non-ICG group [n = 129]). The mean total LNs retrieved in the ICG group significantly exceeds that in the non-ICG group (50.5 ± 15.9 vs 42.0 ± 10.3, P

Date: 2023
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DOI: 10.1038/s41467-023-42712-6

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