Circadian disturbances and frailty risk in older adults

Ruixue Cai (), Lei Gao, Chenlu Gao, Lei Yu, Xi Zheng, David A. Bennett, Aron S. Buchman, Kun Hu and Peng Li ()
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Ruixue Cai: Medical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
Lei Gao: Medical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
Chenlu Gao: Medical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
Lei Yu: Rush University Medical Center
Xi Zheng: Medical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
David A. Bennett: Rush University Medical Center
Aron S. Buchman: Rush University Medical Center
Kun Hu: Medical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
Peng Li: Medical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital

Nature Communications, 2023, vol. 14, issue 1, 1-9

Abstract: Abstract Frailty is characterized by diminished resilience to stressor events. It is associated with adverse future health outcomes and impedes healthy aging. The circadian system orchestrates ~24-h rhythms in bodily functions in synchrony with the day-night cycle, and disturbed circadian regulation plays an important role in many age-related health consequences. We investigated prospective associations of circadian disturbances with incident frailty in over 1000 older adults who had been followed annually for up to 16 years. We found that decreased rhythm strength, reduced stability, or increased variation were associated with a higher risk of incident frailty and faster progress of frailty over time. Perturbed circadian rest-activity rhythms may be an early sign or risk factor for frailty in older adults.

Date: 2023
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DOI: 10.1038/s41467-023-42727-z

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