A smooth tubercle bacillus from Ethiopia phylogenetically close to the Mycobacterium tuberculosis complex

Bazezew Yenew, Arash Ghodousi (), Getu Diriba, Ephrem Tesfaye, Andrea Maurizio Cabibbe, Misikir Amare, Shewki Moga, Ayinalem Alemu, Binyam Dagne, Waganeh Sinshaw, Hilina Mollalign, Abyot Meaza, Mengistu Tadesse, Dinka Fikadu Gamtesa, Yeshiwork Abebaw, Getachew Seid, Betselot Zerihun, Melak Getu, Matteo Chiacchiaretta, Cyril Gaudin, Michael Marceau, Xavier Didelot, Getachew Tolera, Saro Abdella, Abebaw Kebede, Muluwork Getahun, Zemedu Mehammed, Philip Supply () and Daniela Maria Cirillo ()
Additional contact information
Bazezew Yenew: Ethiopian Public Health Institute
Arash Ghodousi: Vita-Salute San Raffaele University
Getu Diriba: Ethiopian Public Health Institute
Ephrem Tesfaye: Ethiopian Public Health Institute
Andrea Maurizio Cabibbe: IRCCS San Raffaele Scientific Institute
Misikir Amare: Ethiopian Public Health Institute
Shewki Moga: Ethiopian Public Health Institute
Ayinalem Alemu: Ethiopian Public Health Institute
Binyam Dagne: Ethiopian Public Health Institute
Waganeh Sinshaw: Ethiopian Public Health Institute
Hilina Mollalign: Ethiopian Public Health Institute
Abyot Meaza: Ethiopian Public Health Institute
Mengistu Tadesse: Ethiopian Public Health Institute
Dinka Fikadu Gamtesa: Ethiopian Public Health Institute
Yeshiwork Abebaw: Ethiopian Public Health Institute
Getachew Seid: Ethiopian Public Health Institute
Betselot Zerihun: Ethiopian Public Health Institute
Melak Getu: Ethiopian Public Health Institute
Matteo Chiacchiaretta: IRCCS San Raffaele Scientific Institute
Cyril Gaudin: Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille
Michael Marceau: Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille
Xavier Didelot: University of Warwick
Getachew Tolera: Ethiopian Public Health Institute
Saro Abdella: Ethiopian Public Health Institute
Abebaw Kebede: Ethiopian Public Health Institute
Muluwork Getahun: Ethiopian Public Health Institute
Zemedu Mehammed: Ethiopian Public Health Institute
Philip Supply: Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille
Daniela Maria Cirillo: Vita-Salute San Raffaele University

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract The Mycobacterium tuberculosis complex (MTBC) includes several human- and animal-adapted pathogens. It is thought to have originated in East Africa from a recombinogenic Mycobacterium canettii-like ancestral pool. Here, we describe the discovery of a clinical tuberculosis strain isolated in Ethiopia that shares archetypal phenotypic and genomic features of M. canettii strains, but represents a phylogenetic branch much closer to the MTBC clade than to the M. canettii strains. Analysis of genomic traces of horizontal gene transfer in this isolate and previously identified M. canettii strains indicates a persistent albeit decreased recombinogenic lifestyle near the emergence of the MTBC. Our findings support that the MTBC emergence from its putative free-living M. canettii-like progenitor is evolutionarily very recent, and suggest the existence of a continuum of further extant derivatives from ancestral stages, close to the root of the MTBC, along the Great Rift Valley.

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42755-9

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DOI: 10.1038/s41467-023-42755-9

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