The lncRNA Sweetheart regulates compensatory cardiac hypertrophy after myocardial injury in murine males

Sandra Rogala, Tamer Ali, Maria-Theodora Melissari, Sandra Währisch, Peggy Schuster, Alexandre Sarre, Rebeca Cordellini Emídio, Thomas Boettger, Eva-Maria Rogg, Jaskiran Kaur, Jaya Krishnan, Gabrijela Dumbović, Stefanie Dimmeler, Samir Ounzain, Thierry Pedrazzini, Bernhard G. Herrmann and Phillip Grote ()
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Sandra Rogala: Goethe University
Tamer Ali: Goethe University
Maria-Theodora Melissari: Goethe University
Sandra Währisch: Max Planck Institute for Molecular Genetics
Peggy Schuster: Goethe University
Alexandre Sarre: University of Lausanne Medical School
Rebeca Cordellini Emídio: Goethe University
Thomas Boettger: Max Planck Institute for Heart- and Lung Research
Eva-Maria Rogg: Goethe University
Jaskiran Kaur: Goethe University
Jaya Krishnan: Goethe University
Gabrijela Dumbović: Goethe University
Stefanie Dimmeler: Goethe University
Samir Ounzain: University of Lausanne Medical School
Thierry Pedrazzini: University of Lausanne Medical School
Bernhard G. Herrmann: Max Planck Institute for Molecular Genetics
Phillip Grote: Goethe University

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract After myocardial infarction in the adult heart the remaining, non-infarcted tissue adapts to compensate the loss of functional tissue. This adaptation requires changes in gene expression networks, which are mostly controlled by transcription regulating proteins. Long non-coding transcripts (lncRNAs) are taking part in fine-tuning such gene programs. We describe and characterize the cardiomyocyte specific lncRNA Sweetheart RNA (Swhtr), an approximately 10 kb long transcript divergently expressed from the cardiac core transcription factor coding gene Nkx2-5. We show that Swhtr is dispensable for normal heart development and function but becomes essential for the tissue adaptation process after myocardial infarction in murine males. Re-expressing Swhtr from an exogenous locus rescues the Swhtr null phenotype. Genes that depend on Swhtr after cardiac stress are significantly occupied and therefore most likely regulated by NKX2-5. The Swhtr transcript interacts with NKX2-5 and disperses upon hypoxic stress in cardiomyocytes, indicating an auxiliary role of Swhtr for NKX2-5 function in tissue adaptation after myocardial injury.

Date: 2023
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DOI: 10.1038/s41467-023-42760-y

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