An on-demand bioresorbable neurostimulator

Dong-Min Lee, Minki Kang, Inah Hyun, Byung-Joon Park, Hye Jin Kim, Soo Hyun Nam, Hong-Joon Yoon, Hanjun Ryu, Hyun-moon Park, Byung-Ok Choi () and Sang-Woo Kim ()
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Dong-Min Lee: Yonsei University
Minki Kang: Sungkyunkwan University (SKKU)
Inah Hyun: Yonsei University
Byung-Joon Park: Yonsei University
Hye Jin Kim: Sungkyunkwan University School of Medicine
Soo Hyun Nam: Samsung Medical Center
Hong-Joon Yoon: Gachon University
Hanjun Ryu: Chung-Ang University
Hyun-moon Park: Energy-Mining Co., LTD.
Byung-Ok Choi: Sungkyunkwan University School of Medicine
Sang-Woo Kim: Yonsei University

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract Bioresorbable bioelectronics, with their natural degradation properties, hold significant potential to eliminate the need for surgical removal. Despite notable achievements, two major challenges hinder their practical application in medical settings. First, they necessitate sustainable energy solutions with biodegradable components via biosafe powering mechanisms. More importantly, reliability in their function is undermined by unpredictable device lifetimes due to the complex polymer degradation kinetics. Here, we propose an on-demand bioresorbable neurostimulator to address these issues, thus allowing for clinical operations to be manipulated using biosafe ultrasound sources. Our ultrasound-mediated transient mechanism enables (1) electrical stimulation through transcutaneous ultrasound-driven triboelectricity and (2) rapid device elimination using high-intensity ultrasound without adverse health effects. Furthermore, we perform neurophysiological analyses to show that our neurostimulator provides therapeutic benefits for both compression peripheral nerve injury and hereditary peripheral neuropathy. We anticipate that the on-demand bioresorbable neurostimulator will prove useful in the development of medical implants to treat peripheral neuropathy.

Date: 2023
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DOI: 10.1038/s41467-023-42791-5

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