Stress-induced red nucleus attenuation induces anxiety-like behavior and lymph node CCL5 secretion

Dong-Dong Shi, Ying-Dan Zhang, Sen Zhang, Bing-Bing Liao, Min-Yi Chu, Shanshan Su, Kaiming Zhuo, Hao Hu, Chen Zhang and Zhen Wang ()
Additional contact information
Dong-Dong Shi: Shanghai Jiao Tong University School of Medicine
Ying-Dan Zhang: Shanghai Jiao Tong University School of Medicine
Sen Zhang: Shanghai Jiao Tong University School of Medicine
Bing-Bing Liao: Shanghai Jiao Tong University School of Medicine
Min-Yi Chu: Shanghai Jiao Tong University School of Medicine
Shanshan Su: Shanghai Jiao Tong University School of Medicine
Kaiming Zhuo: Shanghai Jiao Tong University School of Medicine
Hao Hu: Shanghai Jiao Tong University School of Medicine
Chen Zhang: Shanghai Jiao Tong University School of Medicine
Zhen Wang: Shanghai Jiao Tong University School of Medicine

Nature Communications, 2023, vol. 14, issue 1, 1-17

Abstract: Abstract Previous studies have speculated that brain activity directly controls immune responses in lymphoid organs. However, the upstream brain regions that control lymphoid organs and how they interface with lymphoid organs to produce stress-induced anxiety-like behavior remain elusive. Using stressed human participants and rat models, we show that CCL5 levels are increased in stressed individuals compared to controls. Stress-inducible CCL5 is mainly produced from cervical lymph nodes (CLN). Retrograde tracing from CLN identifies glutamatergic neurons in the red nucleus (RN), the activities of which are tightly correlated with CCL5 levels and anxiety-like behavior in male rats. Ablation or chemogenetic inhibition of RN glutamatergic neurons increases anxiety levels and CCL5 expression in the serum and CLNs, whereas pharmacogenetic activation of these neurons reduces anxiety levels and CCL5 synthesis after restraint stress exposure. Chemogenetic inhibition of the projection from primary motor cortex to RN elicits anxiety-like behavior and CCL5 synthesis. This brain-lymph node axis provides insights into lymph node tissue as a stress-responsive endocrine organ.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-42814-1 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42814-1

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-42814-1

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().