Bioinspired porous three-coordinated single-atom Fe nanozyme with oxidase-like activity for tumor visual identification via glutathione

Da Chen, Zhaoming Xia, Zhixiong Guo, Wangyan Gou, Junlong Zhao, Xuemei Zhou, Xiaohe Tan, Wenbin Li, Shoujie Zhao, Zhimin Tian () and Yongquan Qu ()
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Da Chen: Northwestern Polytechnical University
Zhaoming Xia: Southern University of Science and Technology
Zhixiong Guo: Northwestern Polytechnical University
Wangyan Gou: Northwestern Polytechnical University
Junlong Zhao: Fourth Military Medical University
Xuemei Zhou: Wenzhou University
Xiaohe Tan: Northwestern Polytechnical University
Wenbin Li: Northwestern Polytechnical University
Shoujie Zhao: Fourth Military Medical University
Zhimin Tian: Northwestern Polytechnical University
Yongquan Qu: Northwestern Polytechnical University

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Inspired by structures of natural metalloenzymes, a biomimetic synthetic strategy is developed for scalable synthesis of porous Fe-N3 single atom nanozymes (pFeSAN) using hemoglobin as Fe-source and template. pFeSAN delivers 3.3- and 8791-fold higher oxidase-like activity than Fe-N4 and Fe3O4 nanozymes. The high catalytic performance is attributed to (1) the suppressed aggregation of atomically dispersed Fe; (2) facilitated mass transfer and maximized exposure of active sites for the created mesopores by thermal removal of hemoglobin (2 ~ 3 nm); and (3) unique electronic configuration of Fe-N3 for the oxygen-to-water oxidation pathway (analogy with natural cytochrome c oxidase). The pFeSAN is successfully demonstrated for the rapid colorimetric detection of glutathione with a low limit of detection (2.4 nM) and wide range (50 nM–1 mM), and further developed as a real-time, facile, rapid (~6 min) and precise visualization analysis methodology of tumors via glutathione level, showing its potentials for diagnostic and clinic applications.

Date: 2023
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DOI: 10.1038/s41467-023-42889-w

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