Petal size is controlled by the MYB73/TPL/HDA19-miR159-CKX6 module regulating cytokinin catabolism in Rosa hybrida

Weikun Jing, Feifei Gong, Guoqin Liu, Yinglong Deng, Jiaqi Liu, Wenjing Yang, Xiaoming Sun, Yonghong Li, Junping Gao, Xiaofeng Zhou () and Nan Ma ()
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Weikun Jing: China Agricultural University
Feifei Gong: China Agricultural University
Guoqin Liu: China Agricultural University
Yinglong Deng: China Agricultural University
Jiaqi Liu: China Agricultural University
Wenjing Yang: China Agricultural University
Xiaoming Sun: China Agricultural University
Yonghong Li: Shenzhen Polytechnic
Junping Gao: China Agricultural University
Xiaofeng Zhou: China Agricultural University
Nan Ma: China Agricultural University

Nature Communications, 2023, vol. 14, issue 1, 1-18

Abstract: Abstract The size of plant lateral organs is determined by well-coordinated cell proliferation and cell expansion. Here, we report that miR159, an evolutionarily conserved microRNA, plays an essential role in regulating cell division in rose (Rosa hybrida) petals by modulating cytokinin catabolism. We uncover that Cytokinin Oxidase/Dehydrogenase6 (CKX6) is a target of miR159 in petals. Knocking down miR159 levels results in the accumulation of CKX6 transcripts and earlier cytokinin clearance, leading to a shortened cell division period and smaller petals. Conversely, knocking down CKX6 causes cytokinin accumulation and a prolonged developmental cell division period, mimicking the effects of exogenous cytokinin application. MYB73, a R2R3-type MYB transcription repressor, recruits a co-repressor (TOPLESS) and a histone deacetylase (HDA19) to form a suppression complex, which regulates MIR159 expression by modulating histone H3 lysine 9 acetylation levels at the MIR159 promoter. Our work sheds light on mechanisms for ensuring the correct timing of the exit from the cell division phase and thus organ size regulation by controlling cytokinin catabolism.

Date: 2023
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DOI: 10.1038/s41467-023-42914-y

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