LensAge index as a deep learning-based biological age for self-monitoring the risks of age-related diseases and mortality

Ruiyang Li, Wenben Chen, Mingyuan Li, Ruixin Wang, Lanqin Zhao, Yuanfan Lin, Xinwei Chen, Yuanjun Shang, Xueer Tu, Duoru Lin, Xiaohang Wu, Zhenzhe Lin, Andi Xu, Xun Wang, Dongni Wang, Xulin Zhang, Meimei Dongye, Yunjian Huang, Chuan Chen, Yi Zhu, Chunqiao Liu, Youjin Hu, Ling Zhao, Hong Ouyang, Miaoxin Li, Xuri Li and Haotian Lin ()
Additional contact information
Ruiyang Li: Guangdong Provincial Clinical Research Center for Ocular Diseases
Wenben Chen: Guangdong Provincial Clinical Research Center for Ocular Diseases
Mingyuan Li: Guangdong Provincial Clinical Research Center for Ocular Diseases
Ruixin Wang: Guangdong Provincial Clinical Research Center for Ocular Diseases
Lanqin Zhao: Guangdong Provincial Clinical Research Center for Ocular Diseases
Yuanfan Lin: Guangdong Provincial Clinical Research Center for Ocular Diseases
Xinwei Chen: Guangdong Provincial Clinical Research Center for Ocular Diseases
Yuanjun Shang: Guangdong Provincial Clinical Research Center for Ocular Diseases
Xueer Tu: Guangdong Provincial Clinical Research Center for Ocular Diseases
Duoru Lin: Guangdong Provincial Clinical Research Center for Ocular Diseases
Xiaohang Wu: Guangdong Provincial Clinical Research Center for Ocular Diseases
Zhenzhe Lin: Guangdong Provincial Clinical Research Center for Ocular Diseases
Andi Xu: Guangdong Provincial Clinical Research Center for Ocular Diseases
Xun Wang: Guangdong Provincial Clinical Research Center for Ocular Diseases
Dongni Wang: Guangdong Provincial Clinical Research Center for Ocular Diseases
Xulin Zhang: Guangdong Provincial Clinical Research Center for Ocular Diseases
Meimei Dongye: Guangdong Provincial Clinical Research Center for Ocular Diseases
Yunjian Huang: Guangdong Provincial Clinical Research Center for Ocular Diseases
Chuan Chen: University of Miami Miller School of Medicine
Yi Zhu: University of Miami Miller School of Medicine
Chunqiao Liu: Guangdong Provincial Clinical Research Center for Ocular Diseases
Youjin Hu: Guangdong Provincial Clinical Research Center for Ocular Diseases
Ling Zhao: Guangdong Provincial Clinical Research Center for Ocular Diseases
Hong Ouyang: Guangdong Provincial Clinical Research Center for Ocular Diseases
Miaoxin Li: Sun Yat-sen University
Xuri Li: Guangdong Provincial Clinical Research Center for Ocular Diseases
Haotian Lin: Guangdong Provincial Clinical Research Center for Ocular Diseases

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Age is closely related to human health and disease risks. However, chronologically defined age often disagrees with biological age, primarily due to genetic and environmental variables. Identifying effective indicators for biological age in clinical practice and self-monitoring is important but currently lacking. The human lens accumulates age-related changes that are amenable to rapid and objective assessment. Here, using lens photographs from 20 to 96-year-olds, we develop LensAge to reflect lens aging via deep learning. LensAge is closely correlated with chronological age of relatively healthy individuals (R2 > 0.80, mean absolute errors of 4.25 to 4.82 years). Among the general population, we calculate the LensAge index by contrasting LensAge and chronological age to reflect the aging rate relative to peers. The LensAge index effectively reveals the risks of age-related eye and systemic disease occurrence, as well as all-cause mortality. It outperforms chronological age in reflecting age-related disease risks (p

Date: 2023
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DOI: 10.1038/s41467-023-42934-8

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