CA3 hippocampal synaptic plasticity supports ripple physiology during memory consolidation

Hajer El Oussini, Chun-Lei Zhang, Urielle François, Cecilia Castelli, Aurélie Lampin-Saint-Amaux, Marilyn Lepleux, Pablo Molle, Legeolas Velez, Cyril Dejean, Frederic Lanore, Cyril Herry, Daniel Choquet and Yann Humeau ()
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Hajer El Oussini: University of Bordeaux, CNRS, IINS
Chun-Lei Zhang: University of Bordeaux, CNRS, IINS
Urielle François: University of Bordeaux, CNRS, IINS
Cecilia Castelli: University of Bordeaux, CNRS, IINS
Aurélie Lampin-Saint-Amaux: University of Bordeaux, CNRS, IINS
Marilyn Lepleux: University of Bordeaux, CNRS, IINS
Pablo Molle: University of Bordeaux, CNRS, IINS
Legeolas Velez: University of Bordeaux, CNRS, IINS
Cyril Dejean: University of Bordeaux, INSERM, Neurocentre Magendie
Frederic Lanore: University of Bordeaux, CNRS, IINS
Cyril Herry: University of Bordeaux, INSERM, Neurocentre Magendie
Daniel Choquet: University of Bordeaux, CNRS, IINS
Yann Humeau: University of Bordeaux, CNRS, IINS

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract The consolidation of recent memories depends on memory replays, also called ripples, generated within the hippocampus during slow-wave sleep, and whose inactivation leads to memory impairment. For now, the mobilisation, localisation and importance of synaptic plasticity events associated to ripples are largely unknown. To tackle this question, we used cell surface AMPAR immobilisation to block post-synaptic LTP within the hippocampal region of male mice during a spatial memory task, and show that: 1- hippocampal synaptic plasticity is engaged during consolidation, but is dispensable during encoding or retrieval. 2- Plasticity blockade during sleep results in apparent forgetting of the encoded rule. 3- In vivo ripple recordings show a strong effect of AMPAR immobilisation when a rule has been recently encoded. 4- In situ investigation suggests that plasticity at CA3-CA3 recurrent synapses supports ripple generation. We thus propose that post-synaptic AMPAR mobility at CA3 recurrent synapses is necessary for ripple-dependent rule consolidation.

Date: 2023
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DOI: 10.1038/s41467-023-42969-x

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