Early-to-mid stage idiopathic Parkinson’s disease shows enhanced cytotoxicity and differentiation in CD8 T-cells in females

Christophe M. Capelle, Séverine Ciré, Fanny Hedin, Maxime Hansen, Lukas Pavelka, Kamil Grzyb, Dimitrios Kyriakis, Oliver Hunewald, Maria Konstantinou, Dominique Revets, Vera Tslaf, Tainá M. Marques, Clarissa P. C. Gomes, Alexandre Baron, Olivia Domingues, Mario Gomez, Ni Zeng, Fay Betsou, Patrick May, Alexander Skupin, Antonio Cosma, Rudi Balling, Rejko Krüger, Markus Ollert () and Feng Q. Hefeng ()
Additional contact information
Christophe M. Capelle: Luxembourg Institute of Health (LIH)
Séverine Ciré: Luxembourg Institute of Health (LIH)
Fanny Hedin: Luxembourg Institute of Health (LIH)
Maxime Hansen: University of Luxembourg
Lukas Pavelka: University of Luxembourg
Kamil Grzyb: University of Luxembourg
Dimitrios Kyriakis: University of Luxembourg
Oliver Hunewald: Luxembourg Institute of Health (LIH)
Maria Konstantinou: Luxembourg Institute of Health (LIH)
Dominique Revets: Luxembourg Institute of Health (LIH)
Vera Tslaf: Luxembourg Institute of Health (LIH)
Tainá M. Marques: Luxembourg Institute of Health (LIH)
Clarissa P. C. Gomes: University of Luxembourg
Alexandre Baron: Luxembourg Institute of Health (LIH)
Olivia Domingues: Luxembourg Institute of Health (LIH)
Mario Gomez: Luxembourg Institute of Health (LIH)
Ni Zeng: Luxembourg Institute of Health (LIH)
Fay Betsou: Integrated Biobank of Luxembourg (IBBL), Luxembourg Institute of Health (LIH)
Patrick May: University of Luxembourg
Alexander Skupin: University of Luxembourg
Antonio Cosma: Luxembourg Institute of Health (LIH)
Rudi Balling: University of Luxembourg
Rejko Krüger: University of Luxembourg
Markus Ollert: Luxembourg Institute of Health (LIH)
Feng Q. Hefeng: Luxembourg Institute of Health (LIH)

Nature Communications, 2023, vol. 14, issue 1, 1-21

Abstract: Abstract Neuroinflammation in the brain contributes to the pathogenesis of Parkinson’s disease (PD), but the potential dysregulation of peripheral immunity has not been systematically investigated for idiopathic PD (iPD). Here we showed an elevated peripheral cytotoxic immune milieu, with more terminally-differentiated effector memory (TEMRA) CD8 T, CD8+ NKT cells and circulating cytotoxic molecules in fresh blood of patients with early-to-mid iPD, especially females, after analyzing > 700 innate and adaptive immune features. This profile, also reflected by fewer CD8+FOXP3+ T cells, was confirmed in another subcohort. Co-expression between cytotoxic molecules was selectively enhanced in CD8 TEMRA and effector memory (TEM) cells. Single-cell RNA-sequencing analysis demonstrated the accelerated differentiation within CD8 compartments, enhanced cytotoxic pathways in CD8 TEMRA and TEM cells, while CD8 central memory (TCM) and naïve cells were already more-active and transcriptionally-reprogrammed. Our work provides a comprehensive map of dysregulated peripheral immunity in iPD, proposing candidates for early diagnosis and treatments.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-023-43053-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43053-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-43053-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().