Emergence of task-related spatiotemporal population dynamics in transplanted neurons

Harman Ghuman, Kyungsoo Kim, Sapeeda Barati and Karunesh Ganguly ()
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Harman Ghuman: University of California, San Francisco
Kyungsoo Kim: University of California, San Francisco
Sapeeda Barati: University of California, San Francisco
Karunesh Ganguly: University of California, San Francisco

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Loss of nervous system tissue after severe brain injury is a main determinant of poor functional recovery. Cell transplantation is a promising method to restore lost tissue and function, yet it remains unclear if transplanted neurons can demonstrate the population level dynamics important for movement control. Here we present a comprehensive approach for long-term single neuron monitoring and manipulation of transplanted embryonic cortical neurons after cortical injury in adult male mice performing a prehension task. The observed patterns of population activity in the transplanted network strongly resembled that of healthy networks. Specifically, the task-related spatiotemporal activity patterns of transplanted neurons could be represented by latent factors that evolve within a low dimensional manifold. We also demonstrate reliable modulation of the transplanted networks using minimally invasive epidural stimulation. Our approach may allow greater insight into how restoration of cell-type specific network dynamics in vivo can restore motor function.

Date: 2023
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DOI: 10.1038/s41467-023-43081-w

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