Neutralization of SARS-CoV-2 Omicron BQ.1, BQ.1.1 and XBB.1 variants following SARS-CoV-2 infection or vaccination in children

Lorenza Bellusci, Gabrielle Grubbs, Shaimaa Sait, Lael M. Yonker, Adrienne G. Randolph, Tanya Novak, Takuma Kobayashi and Surender Khurana ()
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Lorenza Bellusci: Center for Biologics Evaluation and Research (CBER), FDA
Gabrielle Grubbs: Center for Biologics Evaluation and Research (CBER), FDA
Shaimaa Sait: Center for Biologics Evaluation and Research (CBER), FDA
Lael M. Yonker: Massachusetts General Hospital for Children, Harvard Medical School
Adrienne G. Randolph: Harvard Medical School
Tanya Novak: Harvard Medical School
Takuma Kobayashi: Critical Care and Pain Medicine, Boston Children’s Hospital
Surender Khurana: Center for Biologics Evaluation and Research (CBER), FDA

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Emergence of highly transmissible Omicron subvariants led to increased SARS-CoV-2 infection and disease in children. However, minimal knowledge exists regarding the neutralization capacity against circulating Omicron BA.4/BA.5, BA.2.75, BQ.1, BQ.1.1 and XBB.1 subvariants following SARS-CoV-2 vaccination in children versus during acute or convalescent COVID-19, or versus multisystem inflammatory syndrome (MIS-C). Here, we evaluate virus-neutralizing capacity against SARS-CoV-2 variants in 151 age-stratified children (

Date: 2023
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DOI: 10.1038/s41467-023-43152-y

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