Diatomic iron nanozyme with lipoxidase-like activity for efficient inactivation of enveloped virus

Beibei Li, Ruonan Ma, Lei Chen, Caiyu Zhou, Yu-Xiao Zhang, Xiaonan Wang, Helai Huang, Qikun Hu, Xiaobo Zheng, Jiarui Yang, Mengjuan Shao, Pengfei Hao, Yanfen Wu, Yizhen Che, Chang Li, Tao Qin, Lizeng Gao (), Zhiqiang Niu () and Yadong Li
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Beibei Li: Tsinghua University
Ruonan Ma: Chinese Academy of Sciences
Lei Chen: Chinese Academy of Sciences
Caiyu Zhou: Chinese Academy of Sciences
Yu-Xiao Zhang: Tsinghua University
Xiaonan Wang: Chinese Academy of Sciences
Helai Huang: Tsinghua University
Qikun Hu: Tsinghua University
Xiaobo Zheng: Tsinghua University
Jiarui Yang: Tsinghua University
Mengjuan Shao: Yangzhou University
Pengfei Hao: Chinese Academy of Agricultural Sciences
Yanfen Wu: Tsinghua University
Yizhen Che: Tsinghua University
Chang Li: Chinese Academy of Agricultural Sciences
Tao Qin: Yangzhou University
Lizeng Gao: Chinese Academy of Sciences
Zhiqiang Niu: Tsinghua University
Yadong Li: Tsinghua University

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract Enveloped viruses encased within a lipid bilayer membrane are highly contagious and can cause many infectious diseases like influenza and COVID-19, thus calling for effective prevention and inactivation strategies. Here, we develop a diatomic iron nanozyme with lipoxidase-like (LOX-like) activity for the inactivation of enveloped virus. The diatomic iron sites can destruct the viral envelope via lipid peroxidation, thus displaying non-specific virucidal property. In contrast, natural LOX exhibits low antiviral performance, manifesting the advantage of nanozyme over the natural enzyme. Theoretical studies suggest that the Fe-O-Fe motif can match well the energy levels of Fe2 minority β-spin d orbitals and pentadiene moiety π* orbitals, and thus significantly lower the activation barrier of cis,cis-1,4-pentadiene moiety in the vesicle membrane. We showcase that the diatomic iron nanozyme can be incorporated into air purifier to disinfect airborne flu virus. The present strategy promises a future application in comprehensive biosecurity control.

Date: 2023
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DOI: 10.1038/s41467-023-43176-4

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