Comprehensive analysis reveals potential therapeutic targets and an integrated risk stratification model for solitary fibrous tumors

Renjing Zhang, Yang Yang, Chunfang Hu, Mayan Huang, Wenjian Cen, Dongyi Ling, Yakang Long, Xin-Hua Yang, Boheng Xu, Junling Peng, Sujie Wang, Weijie Zhu, Mingbiao Wei, Jiaojiao Yang, Yuxia Xu, Xu Zhang, Jiangjun Ma, Fang Wang, Hongtu Zhang, Peiqing Ma, Xiaojun Zhu, Guohui Song, Li-Yue Sun, Wang De-Shen, Feng-Hua Wang, Yu-Hong Li, Sandro Santagata, Qin Li (), Yan-Fen Feng () and Ziming Du ()
Additional contact information
Renjing Zhang: Sun Yat-Sen University Cancer Center
Yang Yang: Sun Yat-sen University
Chunfang Hu: Chinese Academy of Medical Sciences and Peking Union Medical College
Mayan Huang: Sun Yat-Sen University Cancer Center
Wenjian Cen: Sun Yat-Sen University Cancer Center
Dongyi Ling: Sun Yat-Sen University Cancer Center
Yakang Long: Sun Yat-Sen University Cancer Center
Xin-Hua Yang: Sun Yat-Sen University Cancer Center
Boheng Xu: Sun Yat-Sen University Cancer Center
Junling Peng: Sun Yat-Sen University Cancer Center
Sujie Wang: Sun Yat-Sen University Cancer Center
Weijie Zhu: Sun Yat-Sen University Cancer Center
Mingbiao Wei: Sun Yat-Sen University Cancer Center
Jiaojiao Yang: Sun Yat-Sen University Cancer Center
Yuxia Xu: Sun Yat-Sen University Cancer Center
Xu Zhang: Sun Yat-Sen University Cancer Center
Jiangjun Ma: Sun Yat-Sen University Cancer Center
Fang Wang: Sun Yat-Sen University Cancer Center
Hongtu Zhang: Chinese Academy of Medical Sciences and Peking Union Medical College
Peiqing Ma: Chinese Academy of Medical Sciences and Peking Union Medical College
Xiaojun Zhu: Sun Yat-Sen University Cancer Center
Guohui Song: Sun Yat-Sen University Cancer Center
Li-Yue Sun: Guangdong Second Provincial General Hospital
Wang De-Shen: Sun Yat-Sen University Cancer Center
Feng-Hua Wang: Sun Yat-Sen University Cancer Center
Yu-Hong Li: Sun Yat-Sen University Cancer Center
Sandro Santagata: Harvard Medical School
Qin Li: Sun Yat-Sen University
Yan-Fen Feng: Sun Yat-Sen University Cancer Center
Ziming Du: Sun Yat-Sen University Cancer Center

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Solitary fibrous tumors (SFTs) are rare mesenchymal tumors with unpredictable evolution and with a recurrence or metastasis rate of 10-40%. Current medical treatments for relapsed SFTs remain ineffective. Here, we identify potential therapeutic targets and risk factors, including IDH1 p.R132S, high PD-L1 expression, and predominant macrophage infiltration, suggesting the potential benefits of combinational immune therapy and targeted therapy for SFTs. An integrated risk model incorporating mitotic count, density of Ki-67+ cells and CD163+ cells, MTOR mutation is developed, applying a discovery cohort of 101 primary non-CNS patients with negative tumor margins (NTM) and validated in three independent cohorts of 210 SFTs with the same criteria, and in 36 primary CNS SFTs with NTM. Compared with the existing models, our model shows significantly improved efficacy in identifying high-risk primary non-CNS and CNS SFTs with NTM for tumor progression.Our findings hold promise for advancing therapeutic strategies and refining risk prediction in SFTs.

Date: 2023
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DOI: 10.1038/s41467-023-43249-4

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