Proteomic characterization of epithelial ovarian cancer delineates molecular signatures and therapeutic targets in distinct histological subtypes

Ting-Ting Gong, Shuang Guo, Fang-Hua Liu, Yun-Long Huo, Meng Zhang, Shi Yan, Han-Xiao Zhou, Xu Pan, Xin-Yue Wang, He-Li Xu, Ye Kang, Yi-Zi Li, Xue Qin, Qian Xiao, Dong-Hui Huang, Xiao-Ying Li, Yue-Yang Zhao, Xin-Xin Zhao, Ya-Li Wang, Xiao-Xin Ma, Song Gao, Yu-Hong Zhao, Shang-Wei Ning () and Qi-Jun Wu ()
Additional contact information
Ting-Ting Gong: Shengjing Hospital of China Medical University
Shuang Guo: Harbin Medical University
Fang-Hua Liu: Shengjing Hospital of China Medical University
Yun-Long Huo: Shengjing Hospital of China Medical University
Meng Zhang: Shengjing Hospital of China Medical University
Shi Yan: Shengjing Hospital of China Medical University
Han-Xiao Zhou: Harbin Medical University
Xu Pan: Harbin Medical University
Xin-Yue Wang: Harbin Medical University
He-Li Xu: Shengjing Hospital of China Medical University
Ye Kang: Shengjing Hospital of China Medical University
Yi-Zi Li: Shengjing Hospital of China Medical University
Xue Qin: Shengjing Hospital of China Medical University
Qian Xiao: Shengjing Hospital of China Medical University
Dong-Hui Huang: Shengjing Hospital of China Medical University
Xiao-Ying Li: Shengjing Hospital of China Medical University
Yue-Yang Zhao: Shengjing Hospital of China Medical University
Xin-Xin Zhao: Shengjing Hospital of China Medical University
Ya-Li Wang: Shengjing Hospital of China Medical University
Xiao-Xin Ma: Shengjing Hospital of China Medical University
Song Gao: Shengjing Hospital of China Medical University
Yu-Hong Zhao: Shengjing Hospital of China Medical University
Shang-Wei Ning: Harbin Medical University
Qi-Jun Wu: Shengjing Hospital of China Medical University

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Clear cell carcinoma (CCC), endometrioid carcinoma (EC), and serous carcinoma (SC) are the major histological subtypes of epithelial ovarian cancer (EOC), whose differences in carcinogenesis are still unclear. Here, we undertake comprehensive proteomic profiling of 80 CCC, 79 EC, 80 SC, and 30 control samples. Our analysis reveals the prognostic or diagnostic value of dysregulated proteins and phosphorylation sites in important pathways. Moreover, protein co-expression network not only provides comprehensive view of biological features of each histological subtype, but also indicates potential prognostic biomarkers and progression landmarks. Notably, EOC have strong inter-tumor heterogeneity, with significantly different clinical characteristics, proteomic patterns and signaling pathway disorders in CCC, EC, and SC. Finally, we infer MPP7 protein as potential therapeutic target for SC, whose biological functions are confirmed in SC cells. Our proteomic cohort provides valuable resources for understanding molecular mechanisms and developing treatment strategies of distinct histological subtypes.

Date: 2023
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DOI: 10.1038/s41467-023-43282-3

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