Cobalt-catalyzed aminoalkylative carbonylation of alkenes toward direct synthesis of γ-amino acid derivatives and peptides

Le-Cheng Wang, Yang Yuan, Youcan Zhang and Xiao-Feng Wu ()
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Le-Cheng Wang: Dalian Institute of Chemical Physics, Chinese Academy of Sciences
Yang Yuan: Dalian Institute of Chemical Physics, Chinese Academy of Sciences
Youcan Zhang: Dalian Institute of Chemical Physics, Chinese Academy of Sciences
Xiao-Feng Wu: Dalian Institute of Chemical Physics, Chinese Academy of Sciences

Nature Communications, 2023, vol. 14, issue 1, 1-10

Abstract: Abstract γ-Amino acids and peptides analogues are common constituents of building blocks for numerous biologically active molecules, pharmaceuticals, and natural products. In particular, γ-amino acids are providing with better metabolic stability than α-amino acids. Herein we report a multicomponent carbonylation technology that combines readily available amides, alkenes, and the feedstock gas carbon monoxide to build architecturally complex and functionally diverse γ-amino acid derivatives in a single step by the implementation of radical relay catalysis. This transformation can also be used as a late-stage functionalization strategy to deliver complex, advanced γ-amino acid products for pharmaceutical and other areas.

Date: 2023
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DOI: 10.1038/s41467-023-43306-y

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