Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction

Emily S. Lau, Athar Roshandelpoor, Shahrooz Zarbafian, Dongyu Wang, James S. Guseh, Norrina Allen, Vinithra Varadarajan, Matthew Nayor, Ravi V. Shah, Joao A. C. Lima, Sanjiv J. Shah, Bing Yu, Mona Alotaibi, Susan Cheng, Mohit Jain, Gregory D. Lewis and Jennifer E. Ho ()
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Emily S. Lau: Massachusetts General Hospital
Athar Roshandelpoor: Beth Israel Deaconess Medical Center
Shahrooz Zarbafian: Massachusetts General Hospital
Dongyu Wang: Beth Israel Deaconess Medical Center
James S. Guseh: Massachusetts General Hospital
Norrina Allen: Northwestern University Feinberg School of Medicine
Vinithra Varadarajan: Department of Medicine Johns Hopkins University School of Medicine
Matthew Nayor: Boston University School of Medicine
Ravi V. Shah: Vanderbilt University Medical Center
Joao A. C. Lima: Department of Medicine Johns Hopkins University School of Medicine
Sanjiv J. Shah: Northwestern University Feinberg School of Medicine
Bing Yu: University of Texas Health School of Public Health
Mona Alotaibi: University of California San Diego
Susan Cheng: Cedars-Sinai Medical Center
Mohit Jain: University of California San Diego
Gregory D. Lewis: Massachusetts General Hospital
Jennifer E. Ho: Massachusetts General Hospital

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Systemic inflammation has been implicated in the pathobiology of heart failure with preserved ejection fraction (HFpEF). Here, we examine the association of upstream mediators of inflammation as ascertained by fatty-acid derived eicosanoid and eicosanoid-related metabolites with HFpEF status and exercise manifestations of HFpEF. Among 510 participants with chronic dyspnea and preserved LVEF who underwent invasive cardiopulmonary exercise testing, we find that 70 of 890 eicosanoid and related metabolites are associated with HFpEF status, including 17 named and 53 putative eicosanoids (FDR q-value

Date: 2023
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DOI: 10.1038/s41467-023-43363-3

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