A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing

Jinjian Huang, Rong Yang, Jiao Jiao, Ze Li, Penghui Wang, Ye Liu, Sicheng Li, Canwen Chen, Zongan Li, Guiwen Qu, Kang Chen, Xiuwen Wu (), Bo Chi () and Jianan Ren ()
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Jinjian Huang: Nanjing University
Rong Yang: Nanjing Tech University
Jiao Jiao: The First Affiliated Hospital of Nanjing Medical University
Ze Li: Nanjing University
Penghui Wang: Nanjing Tech University
Ye Liu: Southeast University
Sicheng Li: Nanjing University
Canwen Chen: Nanjing University
Zongan Li: Nanjing Normal University
Guiwen Qu: Southeast University
Kang Chen: Nanjing University
Xiuwen Wu: Nanjing University
Bo Chi: Nanjing Tech University
Jianan Ren: Nanjing University

Nature Communications, 2023, vol. 14, issue 1, 1-20

Abstract: Abstract High glucose-induced vascular endothelial injury is a major pathological factor involved in non-healing diabetic wounds. To interrupt this pathological process, we design an all-peptide printable hydrogel platform based on highly efficient and precise one-step click chemistry of thiolated γ-polyglutamic acid, glycidyl methacrylate-conjugated γ-polyglutamic acid, and thiolated arginine-glycine-aspartate sequences. Vascular endothelial growth factor 165-overexpressed human umbilical vein endothelial cells are printed using this platform, hence fabricating a living material with high cell viability and precise cell spatial distribution control. This cell-laden hydrogel platform accelerates the diabetic wound healing of rats based on the unabated vascular endothelial growth factor 165 release, which promotes angiogenesis and alleviates damages on vascular endothelial mitochondria, thereby reducing tissue hypoxia, downregulating inflammation, and facilitating extracellular matrix remodeling. Together, this study offers a promising strategy for fabricating tissue-friendly, high-efficient, and accurate 3D printed all-peptide hydrogel platform for cell delivery and self-renewable growth factor therapy.

Date: 2023
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DOI: 10.1038/s41467-023-43364-2

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