Regulation of species metabolism in synthetic community systems by environmental pH oscillations

Shubin Li, Yingming Zhao, Shuqi Wu, Xiangxiang Zhang, Boyu Yang, Liangfei Tian () and Xiaojun Han ()
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Shubin Li: Harbin Institute of Technology
Yingming Zhao: Harbin Institute of Technology
Shuqi Wu: Zhejiang University
Xiangxiang Zhang: Harbin Institute of Technology
Boyu Yang: Harbin Institute of Technology
Liangfei Tian: Zhejiang University
Xiaojun Han: Harbin Institute of Technology

Nature Communications, 2023, vol. 14, issue 1, 1-10

Abstract: Abstract Constructing a synthetic community system helps scientist understand the complex interactions among species in a community and its environment. Herein, a two-species community is constructed with species A (artificial cells encapsulating pH-responsive molecules and sucrose) and species B (Saccharomyces cerevisiae), which causes the environment to exhibit pH oscillation behaviour due to the generation and dissipation of CO2. In addition, a three-species community is constructed with species A′ (artificial cells containing sucrose and G6P), species B, and species C (artificial cells containing NAD+ and G6PDH). The solution pH oscillation regulates the periodical release of G6P from species A′; G6P then enters species C to promote the metabolic reaction that converts NAD+ to NADH. The location of species A′ and B determines the metabolism behaviour in species C in the spatially coded three-species communities with CA′B, CBA′, and A′CB patterns. The proposed synthetic community system provides a foundation to construct a more complicated microecosystem.

Date: 2023
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DOI: 10.1038/s41467-023-43398-6

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