Intrinsic factors and CD1d1 but not CD1d2 expression levels control invariant natural killer T cell subset differentiation

Ludivine Amable, Luis Antonio Ferreira Martins, Remi Pierre, Marcio Cruseiro, Ghita Chabab, Arnauld Sergé, Camille Kergaravat, Marc Delord, Christophe Viret, Jean Jaubert, Chaohong Liu, Saoussen Karray, Julien C. Marie, Magali Irla, Hristo Georgiev, Emmanuel Clave, Antoine Toubert, Bruno Lucas, Jihene Klibi and Kamel Benlagha ()
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Ludivine Amable: Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), EMiLy
Luis Antonio Ferreira Martins: Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), EMiLy
Remi Pierre: Université Paris Descartes
Marcio Cruseiro: Université Paris Descartes
Ghita Chabab: Tumor Escape Resistance and Immunity department, Cancer Research Center of Lyon INSERM U1052, CNRS UMR 5286, Centre Léon Bérard
Arnauld Sergé: Laboratoire Adhésion Inflammation (LAI), CNRS, INSERM, Aix-Marseille Université
Camille Kergaravat: Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), EMiLy
Marc Delord: King’s College London
Christophe Viret: CIRI, Centre International de Recherche en Infectiologie, Université de Lyon, INSERM U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon
Jean Jaubert: Mouse Genetics Unit, Institut Pasteur
Chaohong Liu: Huazhong University of Science Technology
Saoussen Karray: Université Paris Cité, INSERM U976, Institut de Recherche Saint-Louis (IRSL), Hôpital Saint-Louis
Julien C. Marie: Tumor Escape Resistance and Immunity department, Cancer Research Center of Lyon INSERM U1052, CNRS UMR 5286, Centre Léon Bérard
Magali Irla: Centre d’Immunologie de Marseille-Luminy (CIML), CNRS, INSERM, Aix-Marseille Université
Hristo Georgiev: Hannover Medical School
Emmanuel Clave: Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), EMiLy
Antoine Toubert: Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), EMiLy
Bruno Lucas: Institut Cochin, Centre National de la Recherche Scientifique UMR8104, INSERM U1016, Université Paris Descartes
Jihene Klibi: Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), EMiLy
Kamel Benlagha: Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), EMiLy

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract Invariant natural killer T (NKT) cell subsets are defined based on their cytokine-production profiles and transcription factors. Their distribution is different in C57BL/6 (B6) and BALB/c mice, with a bias for NKT1 and NKT2/NKT17 subsets, respectively. Here, we show that the non-classical class I-like major histocompatibility complex CD1 molecules CD1d2, expressed in BALB/c and not in B6 mice, could not account for this difference. We find however that NKT cell subset distribution is intrinsic to bone marrow derived NKT cells, regardless of syngeneic CD1d-ligand recognition, and that multiple intrinsic factors are likely involved. Finally, we find that CD1d expression levels in combination with T cell antigen receptor signal strength could also influence NKT cell distribution and function. Overall, this study indicates that CD1d-mediated TCR signals and other intrinsic signals integrate to influence strain-specific NKT cell differentiation programs and subset distributions.

Date: 2023
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DOI: 10.1038/s41467-023-43424-7

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