Occlusive membranes for guided regeneration of inflamed tissue defects

Woojin Choi, Utkarsh Mangal, Jin-Young Park, Ji-Yeong Kim, Taesuk Jun, Ju Won Jung, Moonhyun Choi, Sungwon Jung, Milae Lee, Ji-Yeong Na, Du Yeol Ryu, Jin Man Kim, Jae-Sung Kwon, Won-Gun Koh, Sangmin Lee, Patrick T. J. Hwang, Kee-Joon Lee, Ui-Won Jung, Jae-Kook Cha (), Sung-Hwan Choi () and Jinkee Hong ()
Additional contact information
Woojin Choi: Yonsei University
Utkarsh Mangal: Yonsei University College of Dentistry
Jin-Young Park: Yonsei University College of Dentistry
Ji-Yeong Kim: Yonsei University College of Dentistry
Taesuk Jun: Yonsei University
Ju Won Jung: Seoul National University
Moonhyun Choi: Yonsei University
Sungwon Jung: Yonsei University
Milae Lee: Yonsei University
Ji-Yeong Na: Yonsei University College of Dentistry
Du Yeol Ryu: Yonsei University
Jin Man Kim: Seoul National University
Jae-Sung Kwon: Yonsei University College of Dentistry
Won-Gun Koh: Yonsei University
Sangmin Lee: Heukserok-ro, Dongjak-gu
Patrick T. J. Hwang: Rowan University
Kee-Joon Lee: Yonsei University College of Dentistry
Ui-Won Jung: Yonsei University College of Dentistry
Jae-Kook Cha: Yonsei University College of Dentistry
Sung-Hwan Choi: Yonsei University College of Dentistry
Jinkee Hong: Yonsei University

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Guided bone regeneration aided by the application of occlusive membranes is a promising therapy for diverse inflammatory periodontal diseases. Symbiosis, homeostasis between the host microbiome and cells, occurs in the oral environment under normal, but not pathologic, conditions. Here, we develop a symbiotically integrating occlusive membrane by mimicking the tooth enamel growth or multiple nucleation biomineralization processes. We perform human saliva and in vivo canine experiments to confirm that the symbiotically integrating occlusive membrane induces a symbiotic healing environment. Moreover, we show that the membrane exhibits tractability and enzymatic stability, maintaining the healing space during the entire guided bone regeneration therapy period. We apply the symbiotically integrating occlusive membrane to treat inflammatory-challenged cases in vivo, namely, the open and closed healing of canine premolars with severe periodontitis. We find that the membrane promotes symbiosis, prevents negative inflammatory responses, and improves cellular integration. Finally, we show that guided bone regeneration therapy with the symbiotically integrating occlusive membrane achieves fast healing of gingival soft tissue and alveolar bone.

Date: 2023
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DOI: 10.1038/s41467-023-43428-3

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