Health-related quality of life is linked to the gut microbiome in kidney transplant recipients

J. Casper Swarte, Tim J. Knobbe, Johannes R. Björk, Ranko Gacesa, Lianne M. Nieuwenhuis, Shuyan Zhang, Arnau Vich Vila, Daan Kremer, Rianne M. Douwes, Adrian Post, Evelien E. Quint, Robert A. Pol, Bernadien H. Jansen, Martin H. Borst, Vincent E. Meijer, Hans Blokzijl, Stefan P. Berger, Eleonora A. M. Festen, Alexandra Zhernakova, Jingyuan Fu, Hermie J. M. Harmsen, Stephan J. L. Bakker and Rinse K. Weersma ()
Additional contact information
J. Casper Swarte: University of Groningen, University Medical Center Groningen
Tim J. Knobbe: University of Groningen, University Medical Center Groningen
Johannes R. Björk: University of Groningen, University Medical Center Groningen
Ranko Gacesa: University of Groningen, University Medical Center Groningen
Lianne M. Nieuwenhuis: University of Groningen, University Medical Center Groningen
Shuyan Zhang: University of Groningen, University Medical Center Groningen
Arnau Vich Vila: University of Groningen, University Medical Center Groningen
Daan Kremer: University of Groningen, University Medical Center Groningen
Rianne M. Douwes: University of Groningen, University Medical Center Groningen
Adrian Post: University of Groningen, University Medical Center Groningen
Evelien E. Quint: University of Groningen, University Medical Center Groningen
Robert A. Pol: University of Groningen, University Medical Center Groningen
Bernadien H. Jansen: University of Groningen, University Medical Center Groningen
Martin H. Borst: University of Groningen, University Medical Center Groningen
Vincent E. Meijer: University of Groningen, University Medical Center Groningen
Hans Blokzijl: University of Groningen, University Medical Center Groningen
Stefan P. Berger: University of Groningen, University Medical Center Groningen
Eleonora A. M. Festen: University of Groningen, University Medical Center Groningen
Alexandra Zhernakova: University of Groningen, University Medical Center Groningen
Jingyuan Fu: University of Groningen, University Medical Center Groningen
Hermie J. M. Harmsen: University of Groningen, University Medical Center Groningen
Stephan J. L. Bakker: University of Groningen, University Medical Center Groningen
Rinse K. Weersma: University of Groningen, University Medical Center Groningen

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract Kidney transplant recipients (KTR) have impaired health-related quality of life (HRQoL) and suffer from intestinal dysbiosis. Increasing evidence shows that gut health and HRQoL are tightly related in the general population. Here, we investigate the association between the gut microbiome and HRQoL in KTR, using metagenomic sequencing data from fecal samples collected from 507 KTR. Multiple bacterial species are associated with lower HRQoL, many of which have previously been associated with adverse health conditions. Gut microbiome distance to the general population is highest among KTR with an impaired physical HRQoL (R = −0.20, P = 2.3 × 10−65) and mental HRQoL (R = −0.14, P = 1.3 × 10−3). Physical and mental HRQoL explain a significant part of variance in the gut microbiome (R2 = 0.58%, FDR = 5.43 × 10−4 and R2 = 0.37%, FDR = 1.38 × 10−3, respectively). Additionally, multiple metabolic and neuroactive pathways (gut brain modules) are associated with lower HRQoL. While the observational design of our study does not allow us to analyze causality, we provide a comprehensive overview of the associations between the gut microbiome and HRQoL while controlling for confounders.

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43431-8

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DOI: 10.1038/s41467-023-43431-8

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