ANKS1B encoded AIDA-1 regulates social behaviors by controlling oligodendrocyte function

Chang Hoon Cho, Ilana Vasilisa Deyneko, Dylann Cordova-Martinez, Juan Vazquez, Anne S. Maguire, Jenny R. Diaz, Abigail U. Carbonell, Jaafar O. Tindi, Min-Hui Cui, Roman Fleysher, Sophie Molholm, Michael L. Lipton, Craig A. Branch, Louis Hodgson and Bryen A. Jordan ()
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Chang Hoon Cho: Albert Einstein College of Medicine
Ilana Vasilisa Deyneko: Albert Einstein College of Medicine
Dylann Cordova-Martinez: Albert Einstein College of Medicine
Juan Vazquez: Albert Einstein College of Medicine
Anne S. Maguire: Albert Einstein College of Medicine
Jenny R. Diaz: Albert Einstein College of Medicine
Abigail U. Carbonell: Albert Einstein College of Medicine
Jaafar O. Tindi: Albert Einstein College of Medicine
Min-Hui Cui: Albert Einstein College of Medicine
Roman Fleysher: Albert Einstein College of Medicine
Sophie Molholm: Albert Einstein College of Medicine
Michael L. Lipton: Albert Einstein College of Medicine
Craig A. Branch: Albert Einstein College of Medicine
Louis Hodgson: Albert Einstein College of Medicine
Bryen A. Jordan: Albert Einstein College of Medicine

Nature Communications, 2023, vol. 14, issue 1, 1-20

Abstract: Abstract Heterozygous deletions in the ANKS1B gene cause ANKS1B neurodevelopmental syndrome (ANDS), a rare genetic disease characterized by autism spectrum disorder (ASD), attention deficit/hyperactivity disorder, and speech and motor deficits. The ANKS1B gene encodes for AIDA-1, a protein that is enriched at neuronal synapses and regulates synaptic plasticity. Here we report an unexpected role for oligodendroglial deficits in ANDS pathophysiology. We show that Anks1b-deficient mouse models display deficits in oligodendrocyte maturation, myelination, and Rac1 function, and recapitulate white matter abnormalities observed in ANDS patients. Selective loss of Anks1b from the oligodendrocyte lineage, but not from neuronal populations, leads to deficits in social preference and sensory reactivity previously observed in a brain-wide Anks1b haploinsufficiency model. Furthermore, we find that clemastine, an antihistamine shown to increase oligodendrocyte precursor cell maturation and central nervous system myelination, rescues deficits in social preference in 7-month-old Anks1b-deficient mice. Our work shows that deficits in social behaviors present in ANDS may originate from abnormal Rac1 activity within oligodendrocytes.

Date: 2023
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DOI: 10.1038/s41467-023-43438-1

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