Nanoparticles exhibiting virus-mimic surface topology for enhanced oral delivery

Zhentao Sang, Lu Xu, Renyu Ding, Minjun Wang, Xiaoran Yang, Xitan Li, Bingxin Zhou, Kaijun Gou, Yang Han, Tingting Liu, Xuchun Chen, Ying Cheng (), Huazhe Yang () and Heran Li ()
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Zhentao Sang: China Medical University
Lu Xu: Shenyang Pharmaceutical University
Renyu Ding: The First Hospital of China Medical University
Minjun Wang: China Medical University
Xiaoran Yang: China Medical University
Xitan Li: The First Hospital of China Medical University
Bingxin Zhou: China Medical University
Kaijun Gou: The First Hospital of China Medical University
Yang Han: Southwest Minzu University
Tingting Liu: The First Hospital of China Medical University
Xuchun Chen: The First Hospital of China Medical University
Ying Cheng: The First Hospital of China Medical University
Huazhe Yang: China Medical University
Heran Li: China Medical University

Nature Communications, 2023, vol. 14, issue 1, 1-19

Abstract: Abstract The oral delivery of nano-drug delivery systems (Nano-DDS) remains a challenge. Taking inspirations from viruses, here we construct core–shell mesoporous silica nanoparticles (NPs, ~80 nm) with virus-like nanospikes (VSN) to simulate viral morphology, and further modified VSN with L-alanine (CVSN) to enable chiral recognition for functional bionics. By comparing with the solid silica NPs, mesoporous silica NPs and VSN, we demonstrate the delivery advantages of CVSN on overcoming intestinal sequential barriers in both animals and human via multiple biological processes. Subsequently, we encapsulate indomethacin (IMC) into the nanopores of NPs to mimic gene package, wherein the payloads are isolated from bio-environments and exist in an amorphous form to increase their stability and solubility, while the chiral nanospikes multi-sited anchor and chiral recognize on the intestinal mucosa to enhance the penetrability and ultimately improve the oral adsorption of IMC. Encouragingly, we also prove the versatility of CVSN as oral Nano-DDS.

Date: 2023
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DOI: 10.1038/s41467-023-43465-y

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