Diversity of cortical activity changes beyond depression during Spreading Depolarizations

Azat Nasretdinov, Daria Vinokurova, Coline L. Lemale, Gulshat Burkhanova-Zakirova, Ksenia Chernova, Julia Makarova, Oscar Herreras, Jens P. Dreier and Roustem Khazipov ()
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Azat Nasretdinov: Kazan Federal University
Daria Vinokurova: Kazan Federal University
Coline L. Lemale: Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
Gulshat Burkhanova-Zakirova: Kazan Federal University
Ksenia Chernova: Kazan Federal University
Julia Makarova: Cajal Institute—CSIC
Oscar Herreras: Cajal Institute—CSIC
Jens P. Dreier: Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
Roustem Khazipov: Kazan Federal University

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Spreading depolarizations (SDs) are classically thought to be associated with spreading depression of cortical activity. Here, we found that SDs in patients with subarachnoid hemorrhage produce variable, ranging from depression to booming, changes in electrocorticographic activity, especially in the delta frequency band. In rats, depression of activity was characteristic of high-potassium-induced full SDs, whereas partial superficial SDs caused either little change or a boom of activity at the cortical vertex, supported by volume conduction of signals from spared delta generators in the deep cortical layers. Partial SDs also caused moderate neuronal depolarization and sustained excitation, organized in gamma oscillations in a narrow sub-SD zone. Thus, our study challenges the concept of homology between spreading depolarization and spreading depression by showing that SDs produce variable, from depression to booming, changes in activity at the cortical surface and in different cortical layers depending on the depth of SD penetration.

Date: 2023
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DOI: 10.1038/s41467-023-43509-3

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