Associations of myeloid cells with cellular and humoral responses following vaccinations in patients with neuroimmunological diseases

Meng Wang, Adeline Dehlinger, Camila Fernández Zapata, Maya Golan, Gerardina Gallaccio, Leif E. Sander, Stephan Schlickeiser, Desiree Kunkel, Tanja Schmitz-Hübsch, Birgit Sawitzki, Arnon Karni, Julian Braun, Lucie Loyal, Andreas Thiel, Judith Bellmann-Strobl, Friedemann Paul, Lil Meyer-Arndt and Chotima Böttcher ()
Additional contact information
Meng Wang: a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité—Universitätsmedizin Berlin
Adeline Dehlinger: a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité—Universitätsmedizin Berlin
Camila Fernández Zapata: a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité—Universitätsmedizin Berlin
Maya Golan: Sourasky Medical Center, Tel Aviv Sourasky Medical Center
Gerardina Gallaccio: a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité—Universitätsmedizin Berlin
Leif E. Sander: Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
Stephan Schlickeiser: Charité—Universitätsmedizin Berlin, and Berlin Institute of Health Berlin
Desiree Kunkel: Berlin Institute of Health at Charité—Universitätsmedizin Berlin
Tanja Schmitz-Hübsch: a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité—Universitätsmedizin Berlin
Birgit Sawitzki: Berlin Institute of Health at Charité—Universitätsmedizin Berlin
Arnon Karni: Sourasky Medical Center, Tel Aviv Sourasky Medical Center
Julian Braun: Si-M / “Der Simulierte Mensch” a science framework of Technische Universität Berlin and Charité—Universitätsmedizin Berlin
Lucie Loyal: Si-M / “Der Simulierte Mensch” a science framework of Technische Universität Berlin and Charité—Universitätsmedizin Berlin
Andreas Thiel: Si-M / “Der Simulierte Mensch” a science framework of Technische Universität Berlin and Charité—Universitätsmedizin Berlin
Judith Bellmann-Strobl: a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité—Universitätsmedizin Berlin
Friedemann Paul: a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité—Universitätsmedizin Berlin
Lil Meyer-Arndt: Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
Chotima Böttcher: a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité—Universitätsmedizin Berlin

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Disease-modifying therapies (DMTs) are widely used in neuroimmunological diseases such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Although these treatments are known to predispose patients to infections and affect their responses to vaccination, little is known about the impact of DMTs on the myeloid cell compartment. In this study, we use mass cytometry to examine DMT-associated changes in the innate immune system in untreated and treated patients with MS (n = 39) or NMOSD (n = 23). We also investigated the association between changes in myeloid cell phenotypes and longitudinal responsiveness to homologous primary, secondary, and tertiary SARS-CoV-2 mRNA vaccinations. Multiple DMT-associated myeloid cell clusters, in particular CD64+HLADRlow granulocytes, showed significant correlations with B and T cell responses induced by vaccination. Our findings suggest the potential role of myeloid cells in cellular and humoral responses following vaccination in DMT-treated patients with neuroimmunological diseases.

Date: 2023
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DOI: 10.1038/s41467-023-43553-z

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