A self-stabilized and water-responsive deliverable coenzyme-based polymer binary elastomer adhesive patch for treating oral ulcer

Chunyan Cui, Li Mei, Danyang Wang, Pengfei Jia, Qihui Zhou () and Wenguang Liu ()
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Chunyan Cui: Tianjin University
Li Mei: Qingdao University
Danyang Wang: Qingdao University
Pengfei Jia: Qingdao University
Qihui Zhou: University of Health and Rehabilitation Sciences
Wenguang Liu: Tianjin University

Nature Communications, 2023, vol. 14, issue 1, 1-19

Abstract: Abstract Oral ulcer can be treated with diverse biomaterials loading drugs or cytokines. However, most patients do not benefit from these materials because of poor adhesion, short-time retention in oral cavity and low drug therapeutic efficacy. Here we report a self-stabilized and water-responsive deliverable coenzyme salt polymer poly(sodium α-lipoate) (PolyLA-Na)/coenzyme polymer poly(α-lipoic acid) (PolyLA) binary synergistic elastomer adhesive patch, where hydrogen bonding cross-links between PolyLA and PolyLA-Na prevents PolyLA depolymerization and slow down the dissociation of PolyLA-Na, thus allowing water-responsive sustainable delivery of bioactive LA-based small molecules and durable adhesion to oral mucosal wound due to the adhesive action of PolyLA. In the model of mice and mini-pig oral ulcer, the adhesive patch accelerates the healing of the ulcer by regulating the damaged tissue inflammatory environment, maintaining the stability of oral microbiota, and promoting faster re-epithelialization and angiogenesis. This binary synergistic patch provided a therapeutic strategy to treat oral ulcer.

Date: 2023
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DOI: 10.1038/s41467-023-43571-x

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