Dermis resident macrophages orchestrate localized ILC2 eosinophil circuitries to promote non-healing cutaneous leishmaniasis

Sang Hun Lee, Byunghyun Kang, Olena Kamenyeva, Tiago Rodrigues Ferreira, Kyoungin Cho, Jaspal S. Khillan, Juraj Kabat, Brian L. Kelsall and David L. Sacks ()
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Sang Hun Lee: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Byunghyun Kang: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Olena Kamenyeva: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Tiago Rodrigues Ferreira: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Kyoungin Cho: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Jaspal S. Khillan: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Juraj Kabat: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Brian L. Kelsall: National Institute of Allergy and Infectious Diseases, National Institutes of Health
David L. Sacks: National Institute of Allergy and Infectious Diseases, National Institutes of Health

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Tissue-resident macrophages are critical for tissue homeostasis and repair. We previously showed that dermis-resident macrophages produce CCL24 which mediates their interaction with IL-4+ eosinophils, required to maintain their M2-like properties in the TH1 environment of the Leishmania major infected skin. Here, we show that thymic stromal lymphopoietin (TSLP) and IL-5+ type 2 innate lymphoid cells are also required to maintain dermis-resident macrophages and promote infection. Single cell RNA sequencing reveals the dermis-resident macrophages as the sole source of TSLP and CCL24. Generation of Ccl24-cre mice permits specific labeling of dermis-resident macrophages and interstitial macrophages from other organs. Selective ablation of TSLP in dermis-resident macrophages reduces the numbers of IL-5+ type 2 innate lymphoid cells, eosinophils and dermis-resident macrophages, and ameliorates infection. Our findings demonstrate that dermis-resident macrophages are self-maintained as a replicative niche for L. major by orchestrating localized type 2 circuitries with type 2 innate lymphoid cells and eosinophils.

Date: 2023
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DOI: 10.1038/s41467-023-43588-2

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