Holistic bursting cells store long-term memory in auditory cortex

Ruijie Li, Junjie Huang, Longhui Li, Zhikai Zhao, Susu Liang, Shanshan Liang, Meng Wang, Xiang Liao, Jing Lyu, Zhenqiao Zhou, Sibo Wang, Wenjun Jin, Haiyang Chen, Damaris Holder, Hongbang Liu, Jianxiong Zhang, Min Li, Yuguo Tang, Stefan Remy, Janelle M. P. Pakan (), Xiaowei Chen () and Hongbo Jia ()
Additional contact information
Ruijie Li: Guangxi University
Junjie Huang: Chongqing University
Longhui Li: Chongqing University
Zhikai Zhao: Chongqing University
Susu Liang: Chongqing University
Shanshan Liang: Burns, and Combined Injury, Third Military Medical University
Meng Wang: Chongqing University
Xiang Liao: Chongqing University
Jing Lyu: Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences
Zhenqiao Zhou: Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences
Sibo Wang: Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences
Wenjun Jin: Burns, and Combined Injury, Third Military Medical University
Haiyang Chen: Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Damaris Holder: Leibniz Institute for Neurobiology (LIN)
Hongbang Liu: Guangxi University
Jianxiong Zhang: Burns, and Combined Injury, Third Military Medical University
Min Li: Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences
Yuguo Tang: Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences
Stefan Remy: Leibniz Institute for Neurobiology (LIN)
Janelle M. P. Pakan: Otto von Guericke University
Xiaowei Chen: Burns, and Combined Injury, Third Military Medical University
Hongbo Jia: Guangxi University

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract The sensory neocortex has been suggested to be a substrate for long-term memory storage, yet which exact single cells could be specific candidates underlying such long-term memory storage remained neither known nor visible for over a century. Here, using a combination of day-by-day two-photon Ca2+ imaging and targeted single-cell loose-patch recording in an auditory associative learning paradigm with composite sounds in male mice, we reveal sparsely distributed neurons in layer 2/3 of auditory cortex emerged step-wise from quiescence into bursting mode, which then invariably expressed holistic information of the learned composite sounds, referred to as holistic bursting (HB) cells. Notably, it was not shuffled populations but the same sparse HB cells that embodied the behavioral relevance of the learned composite sounds, pinpointing HB cells as physiologically-defined single-cell candidates of an engram underlying long-term memory storage in auditory cortex.

Date: 2023
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DOI: 10.1038/s41467-023-43620-5

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