The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology

Yu-Jun Wang, Gui-Ying Zan, Cenglin Xu, Xue-Ping Li, Xuelian Shu, Song-Yu Yao, Xiao-Shan Xu, Xiaoyun Qiu, Yexiang Chen, Kai Jin, Qi-Xin Zhou, Jia-Yu Ye, Yi Wang, Lin Xu (), Zhong Chen () and Jing-Gen Liu ()
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Yu-Jun Wang: Chinese Academy of Sciences
Gui-Ying Zan: Chinese Academy of Sciences
Cenglin Xu: Zhejiang Chinese Medical University
Xue-Ping Li: Chinese Academy of Sciences
Xuelian Shu: Chinese Academy of Sciences
Song-Yu Yao: Nanjing University of Chinese Medicine
Xiao-Shan Xu: Kunming Institute of Zoology
Xiaoyun Qiu: Zhejiang Chinese Medical University
Yexiang Chen: China Pharmaceutical University
Kai Jin: Kunming Institute of Zoology
Qi-Xin Zhou: Kunming Institute of Zoology
Jia-Yu Ye: Zhejiang Chinese Medical University
Yi Wang: Zhejiang Chinese Medical University
Lin Xu: Kunming Institute of Zoology
Zhong Chen: Zhejiang Chinese Medical University
Jing-Gen Liu: Chinese Academy of Sciences

Nature Communications, 2023, vol. 14, issue 1, 1-17

Abstract: Abstract Ample evidence has suggested the stress etiology of depression, but the underlying mechanism is not fully understood yet. Here, we report that chronic social defeat stress (CSDS) attenuates the excitatory output of the claustrum (CLA) to the prelimbic cortex (PL) through the dynorphin/κ-opioid receptor (KOR) signaling, being critical for depression-related behaviors in male mice. The CSDS preferentially impairs the excitatory output from the CLA onto the parvalbumin (PV) of the PL, leading to PL micronetwork dysfunction by disinhibiting pyramidal neurons (PNs). Optogenetic activation or inhibition of this circuit suppresses or promotes depressive-like behaviors, which is reversed by chemogenetic inhibition or activation of the PV neurons. Notably, manipulating the dynorphin/KOR signaling in the CLA-PL projecting terminals controls depressive-like behaviors that is suppressed or promoted by optogenetic activation or inhibition of CLA-PL circuit. Thus, this study reveals both mechanism of the stress etiology of depression and possibly therapeutic interventions by targeting CLA-PL circuit.

Date: 2023
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DOI: 10.1038/s41467-023-43636-x

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