Prostate cancer genetic risk and associated aggressive disease in men of African ancestry

Pamela X. Y. Soh, Naledi Mmekwa, Desiree C. Petersen, Kazzem Gheybi, Smit van Zyl, Jue Jiang, Sean M. Patrick, Raymond Campbell, Weerachai Jaratlerdseri, Shingai B. A. Mutambirwa, M. S. Riana Bornman and Vanessa M. Hayes ()
Additional contact information
Pamela X. Y. Soh: University of Sydney
Naledi Mmekwa: University of Pretoria
Desiree C. Petersen: Stellenbosch University
Kazzem Gheybi: University of Sydney
Smit van Zyl: University of Limpopo
Jue Jiang: University of Sydney
Sean M. Patrick: University of Pretoria
Raymond Campbell: Phulukisa health Care
Weerachai Jaratlerdseri: University of Sydney
Shingai B. A. Mutambirwa: Sefako Makgatho Health Science University, Dr George Mukhari Academic Hospital
M. S. Riana Bornman: University of Pretoria
Vanessa M. Hayes: University of Sydney

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract African ancestry is a significant risk factor for prostate cancer and advanced disease. Yet, genetic studies have largely been conducted outside the context of Sub-Saharan Africa, identifying 278 common risk variants contributing to a multiethnic polygenic risk score, with rare variants focused on a panel of roughly 20 pathogenic genes. Based on this knowledge, we are unable to determine polygenic risk or differentiate prostate cancer status interrogating whole genome data for 113 Black South African men. To further assess for potentially functional common and rare variant associations, here we interrogate 247,780 exomic variants for 798 Black South African men using a case versus control or aggressive versus non-aggressive study design. Notable genes of interest include HCP5, RFX6 and H3C1 for risk, and MKI67 and KLF5 for aggressive disease. Our study highlights the need for further inclusion across the African diaspora to establish African-relevant risk models aimed at reducing prostate cancer health disparities.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-43726-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43726-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-43726-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().