Opposing brain signatures of sleep in task-based and resting-state conditions

Mohamed Abdelhack, Peter Zhukovsky, Milos Milic, Shreyas Harita, Michael Wainberg, Shreejoy J. Tripathy, John D. Griffiths, Sean L. Hill and Daniel Felsky ()
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Mohamed Abdelhack: Centre for Addiction and Mental Health
Peter Zhukovsky: Centre for Addiction and Mental Health
Milos Milic: Centre for Addiction and Mental Health
Shreyas Harita: Centre for Addiction and Mental Health
Michael Wainberg: Centre for Addiction and Mental Health
Shreejoy J. Tripathy: Centre for Addiction and Mental Health
John D. Griffiths: Centre for Addiction and Mental Health
Sean L. Hill: Centre for Addiction and Mental Health
Daniel Felsky: Centre for Addiction and Mental Health

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract Sleep and depression have a complex, bidirectional relationship, with sleep-associated alterations in brain dynamics and structure impacting a range of symptoms and cognitive abilities. Previous work describing these relationships has provided an incomplete picture by investigating only one or two types of sleep measures, depression, or neuroimaging modalities in parallel. We analyze the correlations between brainwide neural signatures of sleep, cognition, and depression in task and resting-state data from over 30,000 individuals from the UK Biobank and Human Connectome Project. Neural signatures of insomnia and depression are negatively correlated with those of sleep duration measured by accelerometer in the task condition but positively correlated in the resting-state condition. Our results show that resting-state neural signatures of insomnia and depression resemble that of rested wakefulness. This is further supported by our finding of hypoconnectivity in task but hyperconnectivity in resting-state data in association with insomnia and depression. These observations dispute conventional assumptions about the neurofunctional manifestations of hyper- and hypo-somnia, and may explain inconsistent findings in the literature.

Date: 2023
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DOI: 10.1038/s41467-023-43737-7

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