Blazed oblique plane microscopy reveals scale-invariant inference of brain-wide population activity

Maximilian Hoffmann, Jörg Henninger, Johannes Veith, Lars Richter and Benjamin Judkewitz ()
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Maximilian Hoffmann: Charité – Universitätsmedizin Berlin
Jörg Henninger: Charité – Universitätsmedizin Berlin
Johannes Veith: Charité – Universitätsmedizin Berlin
Lars Richter: Ludwig Maximilians University
Benjamin Judkewitz: Charité – Universitätsmedizin Berlin

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract Due to the size and opacity of vertebrate brains, it has until now been impossible to simultaneously record neuronal activity at cellular resolution across the entire adult brain. As a result, scientists are forced to choose between cellular-resolution microscopy over limited fields-of-view or whole-brain imaging at coarse-grained resolution. Bridging the gap between these spatial scales of understanding remains a major challenge in neuroscience. Here, we introduce blazed oblique plane microscopy to perform brain-wide recording of neuronal activity at cellular resolution in an adult vertebrate. Contrary to common belief, we find that inferences of neuronal population activity are near-independent of spatial scale: a set of randomly sampled neurons has a comparable predictive power as the same number of coarse-grained macrovoxels. Our work thus links cellular resolution with brain-wide scope, challenges the prevailing view that macroscale methods are generally inferior to microscale techniques and underscores the value of multiscale approaches to studying brain-wide activity.

Date: 2023
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DOI: 10.1038/s41467-023-43741-x

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