Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes

Yuxi Gao, Lijuan Gao, Endiao Zhu, Yunhong Yang, Mi Jie, Jiaqian Zhang, Zhiqiang Pan () and Chengfeng Xia ()
Additional contact information
Yuxi Gao: Yunnan University
Lijuan Gao: Yunnan University
Endiao Zhu: Yunnan University
Yunhong Yang: Yunnan University
Mi Jie: Yunnan University
Jiaqian Zhang: Yunnan University
Zhiqiang Pan: Yunnan University
Chengfeng Xia: Yunnan University

Nature Communications, 2023, vol. 14, issue 1, 1-9

Abstract: Abstract Alkene dicarbofunctionalization is an efficient strategy and operation-economic fashion for introducing complexity in molecules. A nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes for the simultaneous construction of one C(sp3)−C(sp3) bond and one C(sp3)−C(sp2) bond has been developed. The mild catalytic method provided valuable indanethylamine derivatives with wide substrate scope and good functional group compatibility. An enantioselective dicarbofunctionalization was also achieved with pyridine-oxazoline as a ligand. The efficiency of metallaphotoredox dicarbofunctionalization was demonstrated for the concise synthesis of pharmaceutically active compounds.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-43748-4 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43748-4

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-43748-4

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().