Selective C(sp3)–H arylation/alkylation of alkanes enabled by paired electrocatalysis

Long Zou, Siqi Xiang, Rui Sun and Qingquan Lu ()
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Long Zou: Wuhan University
Siqi Xiang: Wuhan University
Rui Sun: Wuhan University
Qingquan Lu: Wuhan University

Nature Communications, 2023, vol. 14, issue 1, 1-10

Abstract: Abstract We report a combination of electrocatalysis and photoredox catalysis to perform selective C(sp3)–H arylation/alkylation of alkanes, in which a binary catalytic system based on earth-abundant iron and nickel is applied. Reaction selectivity between two-component C(sp3)–H arylation and three-component C(sp3)–H alkylation is tuned by modulating the applied current and light source. Importantly, an ultra-low anodic potential (~0.23 V vs. Ag/AgCl) is applied in this protocol, thus enabling compatibility with a variety of functional groups (>70 examples). The robustness of the method is further demonstrated on a preparative scale and applied to late-stage diversification of natural products and pharmaceutical derivatives.

Date: 2023
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DOI: 10.1038/s41467-023-43791-1

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