An archetype and scaling of developmental tissue dynamics across species

Yoshihiro Morishita (), Sang-Woo Lee, Takayuki Suzuki, Hitoshi Yokoyama, Yasuhiro Kamei, Koji Tamura and Aiko Kawasumi-Kita
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Yoshihiro Morishita: RIKEN Center for Biosystems Dynamics Research
Sang-Woo Lee: RIKEN Center for Biosystems Dynamics Research
Takayuki Suzuki: Osaka Metropolitan University
Hitoshi Yokoyama: Hirosaki University
Yasuhiro Kamei: National Institute for Basic Biology, Myodaiji
Koji Tamura: Tohoku University
Aiko Kawasumi-Kita: RIKEN Center for Biosystems Dynamics Research

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Morphometric studies have revealed the existence of simple geometric relationships among various animal shapes. However, we have little knowledge of the mathematical principles behind the morphogenetic dynamics that form the organ/body shapes of different species. Here, we address this issue by focusing on limb morphogenesis in Gallus gallus domesticus (chicken) and Xenopus laevis (African clawed frog). To compare the deformation dynamics between tissues with different sizes/shapes as well as their developmental rates, we introduce a species-specific rescaled spatial coordinate and a common clock necessary for cross-species synchronization of developmental times. We find that tissue dynamics are well conserved across species under this spacetime coordinate system, at least from the early stages of development through the phase when basic digit patterning is established. For this developmental period, we also reveal that the tissue dynamics of both species are mapped with each other through a time-variant linear transformation in real physical space, from which hypotheses on a species-independent archetype of tissue dynamics and morphogenetic scaling are proposed.

Date: 2023
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DOI: 10.1038/s41467-023-43902-y

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