Theta mediated dynamics of human hippocampal-neocortical learning systems in memory formation and retrieval

Sandra Gattas, Myra Sarai Larson, Lilit Mnatsakanyan, Indranil Sen-Gupta, Sumeet Vadera, A. Lee Swindlehurst, Paul E. Rapp, Jack J. Lin and Michael A. Yassa ()
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Sandra Gattas: University of California
Myra Sarai Larson: University of California
Lilit Mnatsakanyan: University of California
Indranil Sen-Gupta: University of California
Sumeet Vadera: University of California
A. Lee Swindlehurst: University of California
Paul E. Rapp: Uniformed Services University
Jack J. Lin: University of California
Michael A. Yassa: University of California

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract Episodic memory arises as a function of dynamic interactions between the hippocampus and the neocortex, yet the mechanisms have remained elusive. Here, using human intracranial recordings during a mnemonic discrimination task, we report that 4-5 Hz (theta) power is differentially recruited during discrimination vs. overgeneralization, and its phase supports hippocampal-neocortical when memories are being formed and correctly retrieved. Interactions were largely bidirectional, with small but significant net directional biases; a hippocampus-to-neocortex bias during acquisition of new information that was subsequently correctly discriminated, and a neocortex-to-hippocampus bias during accurate discrimination of new stimuli from similar previously learned stimuli. The 4-5 Hz rhythm may facilitate the initial stages of information acquisition by neocortex during learning and the recall of stored information from cortex during retrieval. Future work should further probe these dynamics across different types of tasks and stimuli and computational models may need to be expanded accordingly to accommodate these findings.

Date: 2023
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DOI: 10.1038/s41467-023-44011-6

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