Soft ferroelectret ultrasound receiver for targeted peripheral neuromodulation

Tong Li, Zhidong Wei, Fei Jin, Yongjiu Yuan, Weiying Zheng, Lili Qian, Hongbo Wang, Lisha Hua, Juan Ma, Huanhuan Zhang, Huaduo Gu, Michael G. Irwin, Ting Wang (), Steven Wang (), Zuankai Wang () and Zhang-Qi Feng ()
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Tong Li: Nanjing University of Science and Technology
Zhidong Wei: Nanjing University of Science and Technology
Fei Jin: Nanjing University of Science and Technology
Yongjiu Yuan: City University of Hong Kong
Weiying Zheng: Nanjing University of Science and Technology
Lili Qian: Nanjing University of Science and Technology
Hongbo Wang: City University of Hong Kong
Lisha Hua: City University of Hong Kong
Juan Ma: Nanjing University of Science and Technology
Huanhuan Zhang: City University of Hong Kong
Huaduo Gu: City University of Hong Kong
Michael G. Irwin: The University of Hong Kong
Ting Wang: Southeast University
Steven Wang: City University of Hong Kong
Zuankai Wang: The Hong Kong Polytechnic University
Zhang-Qi Feng: Nanjing University of Science and Technology

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract Bioelectronic medicine is a rapidly growing field where targeted electrical signals can act as an adjunct or alternative to drugs to treat neurological disorders and diseases via stimulating the peripheral nervous system on demand. However, current existing strategies are limited by external battery requirements, and the injury and inflammation caused by the mechanical mismatch between rigid electrodes and soft nerves. Here we report a wireless, leadless, and battery-free ferroelectret implant, termed NeuroRing, that wraps around the target peripheral nerve and demonstrates high mechanical conformability to dynamic motion nerve tissue. As-fabricated NeuroRing can act as an ultrasound receiver that converts ultrasound vibrations into electrostimulation pulses, thus stimulating the targeted peripheral nerve on demand. This capability is demonstrated by the precise modulation of the sacral splanchnic nerve to treat colitis, providing a framework for future bioelectronic medicines that offer an alternative to non-specific pharmacological approaches.

Date: 2023
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DOI: 10.1038/s41467-023-44065-6

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