Phylogeny and molecular evolution of the first local monkeypox virus cluster in Guangdong Province, China

Jianhai Yu, Xin Zhang, Jiajun Liu, Linlin Xiang, Shen Huang, Xiaoting Xie, Ling Fang, Yifan Lin, Meng Zhang, Linqing Wang, Jianfeng He, Bao Zhang, Biao Di, Bo Peng, Jingtao Liang, Chenguang Shen (), Wei Zhao () and Baisheng Li ()
Additional contact information
Jianhai Yu: Southern Medical University
Xin Zhang: Center for Disease Control and Prevention of Guangdong Province
Jiajun Liu: Center for Disease Control and Prevention of Guangdong Province
Linlin Xiang: Southern Medical University
Shen Huang: Center for Disease Control and Prevention of Guangdong Province
Xiaoting Xie: Southern Medical University
Ling Fang: Center for Disease Control and Prevention of Guangdong Province
Yifan Lin: Southern Medical University
Meng Zhang: Center for Disease Control and Prevention of Guangdong Province
Linqing Wang: Southern Medical University
Jianfeng He: Center for Disease Control and Prevention of Guangdong Province
Bao Zhang: Southern Medical University
Biao Di: Guangzhou Center for Disease Control and Prevention
Bo Peng: Shenzhen Center for Disease Control and Prevention
Jingtao Liang: Foshan Center for Disease Control and Prevention
Chenguang Shen: Southern Medical University
Wei Zhao: Southern Medical University
Baisheng Li: Center for Disease Control and Prevention of Guangdong Province

Nature Communications, 2023, vol. 14, issue 1, 1-8

Abstract: Abstract The first local mpox outbreak in Guangdong Province, China occurred in June 2023. However, epidemiological data have failed to quickly identify the source and transmission of the outbreak. Here, phylogeny and molecular evolution of 10 monkeypox virus (MPXV) genome sequences from the Guangdong outbreak were characterized, revealing local silent transmissions that may have occurred in Guangdong whose mpox outbreaks suggested a molecular epidemiological correlation with Portugal and several regions of China during the same period. The lineage IIb C.1, which includes all 10 MPXV from Guangdong, shows consistent temporal continuity in both phylogenetic characteristics and unique molecular evolutionary mutation spectrum, reflected in the continuous increase of single nucleotide polymorphisms (SNPs) and shared mutations over time. Compared with the Japan MPXV, the Guangdong MPXV showed higher genomic nucleotide differences and separated 14 shared mutations from the B.1 lineage, comprising 6 non-synonymous mutations in genes linked to host regulation, virus infection, and virus life cycle. The unique mutation spectrum with temporal continuity in IIb C.1, related to apolipoprotein B mRNA-editing catalytic polypeptide-like 3, promotes rapid viral evolution and diversification. The findings contribute to understanding the ongoing mpox outbreak in China and offer insights for developing joint prevention and control strategies.

Date: 2023
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-44092-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-44092-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-44092-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().