Intranasal mask for protecting the respiratory tract against viral aerosols

Xiaoming Hu, Shuang Wang, Shaotong Fu, Meng Qin, Chengliang Lyu, Zhaowen Ding, Yan Wang, Yishu Wang, Dongshu Wang, Li Zhu, Tao Jiang, Jing Sun, Hui Ding, Jie Wu, Lingqian Chang, Yimin Cui, Xiaocong Pang, Youchun Wang, Weijin Huang, Peidong Yang, Limin Wang (), Guanghui Ma () and Wei Wei ()
Additional contact information
Xiaoming Hu: Chinese Academy of Sciences
Shuang Wang: Chinese Academy of Sciences
Shaotong Fu: University of Chinese Academy of Sciences
Meng Qin: Beijing University of Chemical Technology
Chengliang Lyu: Chinese Academy of Sciences
Zhaowen Ding: Chinese Academy of Sciences
Yan Wang: Chinese Academy of Sciences
Yishu Wang: Chinese Academy of Sciences
Dongshu Wang: Beijing Institute of Biotechnology
Li Zhu: Beijing Institute of Biotechnology
Tao Jiang: Beijing Institute of Microbiology and Epidemiology
Jing Sun: China Academy of Chinese Medical Sciences
Hui Ding: The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital
Jie Wu: Chinese Academy of Sciences
Lingqian Chang: Beihang University
Yimin Cui: Peking University First Hospital
Xiaocong Pang: Peking University First Hospital
Youchun Wang: National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals
Weijin Huang: National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals
Peidong Yang: Affiliated Quanzhou First Hospital of Fujian Medical University
Limin Wang: University of Chinese Academy of Sciences
Guanghui Ma: Chinese Academy of Sciences
Wei Wei: Chinese Academy of Sciences

Nature Communications, 2023, vol. 14, issue 1, 1-20

Abstract: Abstract The spread of many infectious diseases relies on aerosol transmission to the respiratory tract. Here we design an intranasal mask comprising a positively-charged thermosensitive hydrogel and cell-derived micro-sized vesicles with a specific viral receptor. We show that the positively charged hydrogel intercepts negatively charged viral aerosols, while the viral receptor on vesicles mediates the entrapment of viruses for inactivation. We demonstrate that when displaying matched viral receptors, the intranasal masks protect the nasal cavity and lung of mice from either severe acute respiratory syndrome coronavirus 2 or influenza A virus. With computerized tomography images of human nasal cavity, we further conduct computational fluid dynamics simulation and three-dimensional printing of an anatomically accurate human nasal cavity, which is connected to human lung organoids to generate a human respiratory tract model. Both simulative and experimental results support the suitability of intranasal masks in humans, as the likelihood of viral respiratory infections induced by different variant strains is dramatically reduced.

Date: 2023
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DOI: 10.1038/s41467-023-44134-w

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