Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry

Michael A. Skinnider, Mopelola O. Akinlaja and Leonard J. Foster ()
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Michael A. Skinnider: University of British Columbia
Mopelola O. Akinlaja: University of British Columbia
Leonard J. Foster: University of British Columbia

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract We present CFdb, a harmonized resource of interaction proteomics data from 411 co-fractionation mass spectrometry (CF-MS) datasets spanning 21,703 fractions. Meta-analysis of this resource charts protein abundance, phosphorylation, and interactions throughout the tree of life, including a reference map of the human interactome. We show how large-scale CF-MS data can enhance analyses of individual CF-MS datasets, and exemplify this strategy by mapping the honey bee interactome.

Date: 2023
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DOI: 10.1038/s41467-023-44139-5

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