Hypothalamic CRH neurons represent physiological memory of positive and negative experience

Tamás Füzesi, Neilen P. Rasiah, David G. Rosenegger, Mijail Rojas-Carvajal, Taylor Chomiak, Núria Daviu, Leonardo A. Molina, Kathryn Simone, Toni-Lee Sterley, Wilten Nicola and Jaideep S. Bains ()
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Tamás Füzesi: University of Calgary
Neilen P. Rasiah: University of Calgary
David G. Rosenegger: University of Calgary
Mijail Rojas-Carvajal: University of Calgary
Taylor Chomiak: University of Calgary
Núria Daviu: University of Calgary
Leonardo A. Molina: University of Calgary
Kathryn Simone: University of Calgary
Toni-Lee Sterley: University of Calgary
Wilten Nicola: University of Calgary
Jaideep S. Bains: University of Calgary

Nature Communications, 2023, vol. 14, issue 1, 1-12

Abstract: Abstract Recalling a salient experience provokes specific behaviors and changes in the physiology or internal state. Relatively little is known about how physiological memories are encoded. We examined the neural substrates of physiological memory by probing CRHPVN neurons of mice, which control the endocrine response to stress. Here we show these cells exhibit contextual memory following exposure to a stimulus with negative or positive valence. Specifically, a negative stimulus invokes a two-factor learning rule that favors an increase in the activity of weak cells during recall. In contrast, the contextual memory of positive valence relies on a one-factor rule to decrease activity of CRHPVN neurons. Finally, the aversive memory in CRHPVN neurons outlasts the behavioral response. These observations provide information about how specific physiological memories of aversive and appetitive experience are represented and demonstrate that behavioral readouts may not accurately reflect physiological changes invoked by the memory of salient experiences.

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-44163-5

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DOI: 10.1038/s41467-023-44163-5

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