Magnaporthe oryzae effector MoSPAB1 directly activates rice Bsr-d1 expression to facilitate pathogenesis

Ziwei Zhu, Jun Xiong, Hao Shi, Yuchen Liu, Junjie Yin, Kaiwei He, Tianyu Zhou, Liting Xu, Xiaobo Zhu, Xiang Lu, Yongyan Tang, Li Song, Qingqing Hou, Qing Xiong, Long Wang, Daihua Ye, Tuo Qi, Lijuan Zou, Guobang Li, Changhui Sun, Zhiyue Wu, Peili Li, Jiali Liu, Yu Bi, Yihua Yang, Chunxian Jiang, Jing Fan, Guoshu Gong, Min He, Jing Wang, Xuewei Chen () and Weitao Li ()
Additional contact information
Ziwei Zhu: Sichuan Agricultural University
Jun Xiong: Sichuan Agricultural University
Hao Shi: Sichuan Agricultural University
Yuchen Liu: Sichuan Agricultural University
Junjie Yin: Sichuan Agricultural University
Kaiwei He: Sichuan Agricultural University
Tianyu Zhou: Sichuan Agricultural University
Liting Xu: Sichuan Agricultural University
Xiaobo Zhu: Sichuan Agricultural University
Xiang Lu: Sichuan Agricultural University
Yongyan Tang: Sichuan Agricultural University
Li Song: Sichuan Agricultural University
Qingqing Hou: Sichuan Agricultural University
Qing Xiong: Sichuan Agricultural University
Long Wang: Sichuan Agricultural University
Daihua Ye: Sichuan Agricultural University
Tuo Qi: Mianyang Teachers’ College
Lijuan Zou: Mianyang Teachers’ College
Guobang Li: Sichuan Agricultural University
Changhui Sun: Sichuan Agricultural University
Zhiyue Wu: Sichuan Agricultural University
Peili Li: Sichuan Agricultural University
Jiali Liu: Sichuan Agricultural University
Yu Bi: Sichuan Agricultural University
Yihua Yang: Sichuan Agricultural University
Chunxian Jiang: Sichuan Agricultural University
Jing Fan: Sichuan Agricultural University
Guoshu Gong: Sichuan Agricultural University
Min He: Sichuan Agricultural University
Jing Wang: Sichuan Agricultural University
Xuewei Chen: Sichuan Agricultural University
Weitao Li: Sichuan Agricultural University

Nature Communications, 2023, vol. 14, issue 1, 1-12

Abstract: Abstract Fungal pathogens typically use secreted effector proteins to suppress host immune activators to facilitate invasion. However, there is rarely evidence supporting the idea that fungal secretory proteins contribute to pathogenesis by transactivating host genes that suppress defense. We previously found that pathogen Magnaporthe oryzae induces rice Bsr-d1 to facilitate infection and hypothesized that a fungal effector mediates this induction. Here, we report that MoSPAB1 secreted by M. oryzae directly binds to the Bsr-d1 promoter to induce its expression, facilitating pathogenesis. Amino acids 103-123 of MoSPAB1 are required for its binding to the Bsr-d1 promoter. Both MoSPAB1 and rice MYBS1 compete for binding to the Bsr-d1 promoter to regulate Bsr-d1 expression. Furthermore, MoSPAB1 homologues are highly conserved among fungi. In particular, Colletotrichum fructicola CfSPAB1 and Colletotrichum sublineola CsSPAB1 activate kiwifruit AcBsr-d1 and sorghum SbBsr-d1 respectively, to facilitate pathogenesis. Taken together, our findings reveal a conserved module that may be widely utilized by fungi to enhance pathogenesis.

Date: 2023
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DOI: 10.1038/s41467-023-44197-9

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