A unique sigma/anti-sigma system in the actinomycete Actinoplanes missouriensis

Takeaki Tezuka (), Kyota Mitsuyama, Risa Date and Yasuo Ohnishi ()
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Takeaki Tezuka: The University of Tokyo
Kyota Mitsuyama: The University of Tokyo
Risa Date: The University of Tokyo
Yasuo Ohnishi: The University of Tokyo

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract Bacteria of the genus Actinoplanes form sporangia that contain dormant sporangiospores which, upon contact with water, release motile spores (zoospores) through a process called sporangium dehiscence. Here, we set out to study the molecular mechanisms behind sporangium dehiscence in Actinoplanes missouriensis and discover a sigma/anti-sigma system with unique features. Protein σSsdA contains a functional sigma factor domain and an anti-sigma factor antagonist domain, while protein SipA contains an anti-sigma factor domain and an anti-sigma factor antagonist domain. Remarkably, the two proteins interact with each other via the anti-sigma factor antagonist domain of σSsdA and the anti-sigma factor domain of SipA. Although it remains unclear whether the SipA/σSsdA system plays direct roles in sporangium dehiscence, the system seems to modulate oxidative stress responses in zoospores. In addition, we identify a two-component regulatory system (RsdK-RsdR) that represses initiation of sporangium dehiscence.

Date: 2023
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DOI: 10.1038/s41467-023-44291-y

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