Quantum plasmonics pushes chiral sensing limit to single molecules: a paradigm for chiral biodetections

Chi Zhang, Huatian Hu, Chunmiao Ma, Yawen Li, Xujie Wang, Dongyao Li, Artur Movsesyan, Zhiming Wang, Alexander Govorov, Quan Gan () and Tao Ding ()
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Chi Zhang: Wuhan University
Huatian Hu: Wuhan Institute of Technology
Chunmiao Ma: Huazhong University of Science and Technology
Yawen Li: Wuhan University
Xujie Wang: Wuhan University
Dongyao Li: Huazhong University of Science and Technology
Artur Movsesyan: University of Electronic Science and Technology of China
Zhiming Wang: University of Electronic Science and Technology of China
Alexander Govorov: Ohio University
Quan Gan: Huazhong University of Science and Technology
Tao Ding: Wuhan University

Nature Communications, 2024, vol. 15, issue 1, 1-8

Abstract: Abstract Chiral sensing of single molecules is vital for the understanding of chirality and their applications in biomedicine. However, current technologies face severe limitations in achieving single-molecule sensitivity. Here we overcome these limitations by designing a tunable chiral supramolecular plasmonic system made of helical oligoamide sequences (OS) and nanoparticle-on-mirror (NPoM) resonator, which works across the classical and quantum regimes. Our design enhances the chiral sensitivity in the quantum tunnelling regime despite of the reduced local E-field, which is due to the strong Coulomb interactions between the chiral OSs and the achiral NPoMs and the additional enhancement from tunnelling electrons. A minimum of four molecules per single-Au particle can be detected, which allows for the detection of an enantiomeric excess within a monolayer, manifesting great potential for the chiral sensing of single molecules.

Date: 2024
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DOI: 10.1038/s41467-023-42719-z

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