All-in-one porous membrane enables full protection in guided bone regeneration

Shuyi Wu, Shulu Luo, Zongheng Cen, Qianqian Li, Luwei Li, Weiran Li, Zhike Huang, Wenyi He, Guobin Liang, Dingcai Wu (), Minghong Zhou () and Yan Li ()
Additional contact information
Shuyi Wu: Sun Yat-sen University
Shulu Luo: Sun Yat-sen University
Zongheng Cen: Sun Yat-sen University
Qianqian Li: Sun Yat-sen University
Luwei Li: Sun Yat-sen University
Weiran Li: Sun Yat-sen University
Zhike Huang: Southern Medical University
Wenyi He: Sun Yat-sen University
Guobin Liang: Sun Yat-sen University
Dingcai Wu: Sun Yat-sen University
Minghong Zhou: Southern Medical University
Yan Li: Sun Yat-sen University

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract The sophisticated hierarchical structure that precisely combines contradictory mechanical and biological characteristics is ideal for biomaterials, but it is challenging to achieve. Herein, we engineer a spatiotemporally hierarchical guided bone regeneration (GBR) membrane by rational bilayer integration of densely porous N-halamine functionalized bacterial cellulose nanonetwork facing the gingiva and loosely porous chitosan-hydroxyapatite composite micronetwork facing the alveolar bone. Our GBR membrane asymmetrically combine stiffness and flexibility, ingrowth barrier and ingrowth guiding, as well as anti-bacteria and cell-activation. The dense layer has a mechanically matched space maintenance capacity toward gingiva, continuously blocks fibroblasts, and prevents bacterial invasion with multiple mechanisms including release-killing, contact-killing, anti-adhesion, and nanopore-blocking; the loose layer is ultra-soft to conformally cover bone surfaces and defect cavity edges, enables ingrowth of osteogenesis-associated cells, and creates a favorable osteogenic microenvironment. As a result, our all-in-one porous membrane possesses full protective abilities in GBR.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-43476-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-43476-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-43476-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().