Flexible, scalable, high channel count stereo-electrode for recording in the human brain

Keundong Lee, Angelique C. Paulk, Yun Goo Ro, Daniel R. Cleary, Karen J. Tonsfeldt, Yoav Kfir, John S. Pezaris, Youngbin Tchoe, Jihwan Lee, Andrew M. Bourhis, Ritwik Vatsyayan, Joel R. Martin, Samantha M. Russman, Jimmy C. Yang, Amy Baohan, R. Mark Richardson, Ziv M. Williams, Shelley I. Fried, U. Hoi Sang, Ahmed M. Raslan, Sharona Ben-Haim, Eric Halgren, Sydney S. Cash and Shadi. A. Dayeh ()
Additional contact information
Keundong Lee: University of California San Diego
Angelique C. Paulk: Harvard Medical School
Yun Goo Ro: University of California San Diego
Daniel R. Cleary: University of California San Diego
Karen J. Tonsfeldt: University of California San Diego
Yoav Kfir: Harvard Medical School
John S. Pezaris: Harvard Medical School
Youngbin Tchoe: University of California San Diego
Jihwan Lee: University of California San Diego
Andrew M. Bourhis: University of California San Diego
Ritwik Vatsyayan: University of California San Diego
Joel R. Martin: University of California San Diego
Samantha M. Russman: University of California San Diego
Jimmy C. Yang: Harvard Medical School
Amy Baohan: Harvard Medical School
R. Mark Richardson: Harvard Medical School
Ziv M. Williams: Harvard Medical School
Shelley I. Fried: Harvard Medical School
U. Hoi Sang: University of California San Diego
Ahmed M. Raslan: Oregon Health and Science University
Sharona Ben-Haim: University of California San Diego
Eric Halgren: University of California San Diego
Sydney S. Cash: Harvard Medical School
Shadi. A. Dayeh: University of California San Diego

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Over the past decade, stereotactically placed electrodes have become the gold standard for deep brain recording and stimulation for a wide variety of neurological and psychiatric diseases. Current electrodes, however, are limited in their spatial resolution and ability to record from small populations of neurons, let alone individual neurons. Here, we report on an innovative, customizable, monolithically integrated human-grade flexible depth electrode capable of recording from up to 128 channels and able to record at a depth of 10 cm in brain tissue. This thin, stylet-guided depth electrode is capable of recording local field potentials and single unit neuronal activity (action potentials), validated across species. This device represents an advance in manufacturing and design approaches which extends the capabilities of a mainstay technology in clinical neurology.

Date: 2024
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DOI: 10.1038/s41467-023-43727-9

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