Metallopolymer strategy to explore hypoxic active narrow-bandgap photosensitizers for effective cancer photodynamic therapy

Zhao Zhang, Zixiang Wei, Jintong Guo, Jinxiao Lyu, Bingzhe Wang, Gang Wang, Chunfei Wang, Liqiang Zhou, Zhen Yuan, Guichuan Xing, Changfeng Wu and Xuanjun Zhang ()
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Zhao Zhang: University of Macau
Zixiang Wei: University of Macau
Jintong Guo: University of Macau
Jinxiao Lyu: University of Macau
Bingzhe Wang: University of Macau
Gang Wang: University of Macau
Chunfei Wang: University of Macau
Liqiang Zhou: University of Macau
Zhen Yuan: University of Macau
Guichuan Xing: University of Macau
Changfeng Wu: Southern University of Science and Technology
Xuanjun Zhang: University of Macau

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Practical photodynamic therapy calls for high-performance, less O2-dependent, long-wavelength-light-activated photosensitizers to suit the hypoxic tumor microenvironment. Iridium-based photosensitizers exhibit excellent photocatalytic performance, but the in vivo applications are hindered by conventional O2-dependent Type-II photochemistry and poor absorption. Here we show a general metallopolymerization strategy for engineering iridium complexes exhibiting Type-I photochemistry and enhancing absorption intensity in the blue to near-infrared region. Reactive oxygen species generation of metallopolymer Ir-P1, where the iridium atom is covalently coupled to the polymer backbone, is over 80 times higher than that of its mother polymer without iridium under 680 nm irradiation. This strategy also works effectively when the iridium atom is directly included (Ir-P2) in the polymer backbones, exhibiting wide generality. The metallopolymer nanoparticles exhibiting efficient O2•− generation are conjugated with integrin αvβ3 binding cRGD to achieve targeted photodynamic therapy.

Date: 2024
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DOI: 10.1038/s41467-023-43890-z

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